Early response to light therapy partially predicts long-term antidepressant effects in patients with seasonal affective disorder

L. Sher, J. R. Matthews, Erick Turner, T. T. Postolache, K. S. Katz, N. E. Rosenthal

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To determine if the antidepressant effect of 1 hour of light therapy is predictive of the response after 1 and 2 weeks of treatment in patients with seasonal affective disorder (SAD). Patients: Twelve patients with SAD. Setting: National Institutes of Health Clinical Center, Bethesda, Md. Interventions: Light therapy for 2 weeks. Outcome measures: Scores on the Seasonal Affective Disorder Version of the Hamilton Depression Rating Scale (SIGH-SAD) on 4 occasions (before and after 1 hour of light therapy and after 1 and 2 weeks of therapy) in the winter when the patients were depressed. Change on typical and atypical depressive scores at these time points were compared. Results: Improvement of atypical depressive symptoms after 1 hour of light therapy positively correlated with improvement after 2 weeks of therapy. Conclusion: In patients with SAD, the early response to light therapy may predict some aspects of long-term response to light therapy, but these results should be treated with caution until replicated.

Original languageEnglish (US)
Pages (from-to)336-338
Number of pages3
JournalJournal of Psychiatry and Neuroscience
Volume26
Issue number4
StatePublished - 2001
Externally publishedYes

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Seasonal Affective Disorder
Phototherapy
Antidepressive Agents
Depression
National Institutes of Health (U.S.)
Therapeutics
Outcome Assessment (Health Care)

Keywords

  • Depression
  • Mood disorders
  • Phototherapy
  • Seasonal affective disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Early response to light therapy partially predicts long-term antidepressant effects in patients with seasonal affective disorder. / Sher, L.; Matthews, J. R.; Turner, Erick; Postolache, T. T.; Katz, K. S.; Rosenthal, N. E.

In: Journal of Psychiatry and Neuroscience, Vol. 26, No. 4, 2001, p. 336-338.

Research output: Contribution to journalArticle

Sher, L. ; Matthews, J. R. ; Turner, Erick ; Postolache, T. T. ; Katz, K. S. ; Rosenthal, N. E. / Early response to light therapy partially predicts long-term antidepressant effects in patients with seasonal affective disorder. In: Journal of Psychiatry and Neuroscience. 2001 ; Vol. 26, No. 4. pp. 336-338.
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