Early Pregnancy Losses

Review of Nomenclature, Histopathology, and Possible Etiologies

M. Halit Pinar, Karen Gibbins, Mai He, Stefan Kostadinov, Robert Silver

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Miscarriage is a frequent complication of human pregnancy: ∼50% to 70% of spontaneous conceptions are lost prior to the second trimester. Etiology of miscarriage includes genetic abnormalities, infections, immunological and implantation disorders, uterine and endocrine abnormalities, and lifestyle factors. Given such variability, knowledge regarding causes, pathophysiological mechanisms, and morphologies of primary early pregnancy loss has significant gaps; often, pregnancy losses remain unexplained. Pathologic evaluation of miscarriage tissue is an untapped source of knowledge. Although miscarriage specimens comprise a significant part of pathologists' workload, information reported from these specimens is typically of minimal clinical utility for delineating etiology or predicting recurrence risk. Standardized terminology is available, though not universally used. We reintroduce the terminology and review new information about early pregnancy losses and their morphologies. Current clinical terminology is inconsistent, hampering research progress. This review is a resource for diagnostic pathologists studying this complex problem.

Original languageEnglish (US)
Pages (from-to)191-209
Number of pages19
JournalFetal and Pediatric Pathology
Volume37
Issue number3
DOIs
StatePublished - May 4 2018
Externally publishedYes

Fingerprint

Spontaneous Abortion
Terminology
Pregnancy
Pregnancy Complications
Second Pregnancy Trimester
Workload
Life Style
Recurrence
Infection
Research
Pathologists

Keywords

  • Early pregnancy loss
  • histopathology
  • miscarriage
  • nomenclature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Early Pregnancy Losses : Review of Nomenclature, Histopathology, and Possible Etiologies. / Pinar, M. Halit; Gibbins, Karen; He, Mai; Kostadinov, Stefan; Silver, Robert.

In: Fetal and Pediatric Pathology, Vol. 37, No. 3, 04.05.2018, p. 191-209.

Research output: Contribution to journalReview article

Pinar, M. Halit ; Gibbins, Karen ; He, Mai ; Kostadinov, Stefan ; Silver, Robert. / Early Pregnancy Losses : Review of Nomenclature, Histopathology, and Possible Etiologies. In: Fetal and Pediatric Pathology. 2018 ; Vol. 37, No. 3. pp. 191-209.
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