Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success

David Seifer, K. L. Thornton, A. H. DeCherney, G. Lavy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To determine if the timing of the onset of pituitary desensitization and ovarian suppression using follicular phase leuprolide acetate (LA) is associated with in vitro fertilization-embryo transfer (IVF-ET) success for pregnancy. Design: Retrospective series of IVF patients undergoing pituitary desensitization and ovarian suppression before beginning controlled ovarian hyperstimulation for IVF-ET. Setting: Tertiary infertility practice. Patients: Seventy-eight women for 80 cycles began LA on day 1 of their menstrual cycle. After 11 days of LA, 47 (59%) cycles in group I had suppressed serum estradiol (E2) levels <40 pg/mL, in contrast to 33 (41%) cycles in group II not adequately suppressed, thereby requiring additional days to achieve suppression. Interventions: Controlled ovarian hyperstimulation was started when patients were satisfactorily suppressed, i.e., E2 <40 pg/mL. Main Outcome Measure(s): Mean E2 response, ampules of human menopausal gonadotropin, cancellation rates, number of oocytes retrieved, fertilization rates, and pregnancy rates (PRs) per cycle were examined between groups I and II. Results: Group I demonstrated a greater mean E2 response on the day of human chorionic gonadotropin 1,735 pg/mL versus 1,470 pg/mL (P = 0.008), a greater fertilization rate 64% versus 55% (P = 0.02), and a higher PR per cycle 34% versus 12% (P = 0.036) compared with group II. Conclusions: Women who achieved desensitization-suppression within 11 days of initiating LA demonstrated a more favorable outcome for IVF-ET than those who did not.

Original languageEnglish (US)
Pages (from-to)500-504
Number of pages5
JournalFertility and Sterility
Volume56
Issue number3
StatePublished - 1991
Externally publishedYes

Fingerprint

Leuprolide
Embryo Transfer
Fertilization in Vitro
Pregnancy Rate
Fertilization
Menotropins
Follicular Phase
Chorionic Gonadotropin
Menstrual Cycle
Infertility
Oocytes
Estradiol
Outcome Assessment (Health Care)
Pregnancy
Serum

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success. / Seifer, David; Thornton, K. L.; DeCherney, A. H.; Lavy, G.

In: Fertility and Sterility, Vol. 56, No. 3, 1991, p. 500-504.

Research output: Contribution to journalArticle

@article{9a38c102ee024353ba13c7cbe60430fc,
title = "Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success",
abstract = "Objective: To determine if the timing of the onset of pituitary desensitization and ovarian suppression using follicular phase leuprolide acetate (LA) is associated with in vitro fertilization-embryo transfer (IVF-ET) success for pregnancy. Design: Retrospective series of IVF patients undergoing pituitary desensitization and ovarian suppression before beginning controlled ovarian hyperstimulation for IVF-ET. Setting: Tertiary infertility practice. Patients: Seventy-eight women for 80 cycles began LA on day 1 of their menstrual cycle. After 11 days of LA, 47 (59{\%}) cycles in group I had suppressed serum estradiol (E2) levels <40 pg/mL, in contrast to 33 (41{\%}) cycles in group II not adequately suppressed, thereby requiring additional days to achieve suppression. Interventions: Controlled ovarian hyperstimulation was started when patients were satisfactorily suppressed, i.e., E2 <40 pg/mL. Main Outcome Measure(s): Mean E2 response, ampules of human menopausal gonadotropin, cancellation rates, number of oocytes retrieved, fertilization rates, and pregnancy rates (PRs) per cycle were examined between groups I and II. Results: Group I demonstrated a greater mean E2 response on the day of human chorionic gonadotropin 1,735 pg/mL versus 1,470 pg/mL (P = 0.008), a greater fertilization rate 64{\%} versus 55{\%} (P = 0.02), and a higher PR per cycle 34{\%} versus 12{\%} (P = 0.036) compared with group II. Conclusions: Women who achieved desensitization-suppression within 11 days of initiating LA demonstrated a more favorable outcome for IVF-ET than those who did not.",
author = "David Seifer and Thornton, {K. L.} and DeCherney, {A. H.} and G. Lavy",
year = "1991",
language = "English (US)",
volume = "56",
pages = "500--504",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success

AU - Seifer, David

AU - Thornton, K. L.

AU - DeCherney, A. H.

AU - Lavy, G.

PY - 1991

Y1 - 1991

N2 - Objective: To determine if the timing of the onset of pituitary desensitization and ovarian suppression using follicular phase leuprolide acetate (LA) is associated with in vitro fertilization-embryo transfer (IVF-ET) success for pregnancy. Design: Retrospective series of IVF patients undergoing pituitary desensitization and ovarian suppression before beginning controlled ovarian hyperstimulation for IVF-ET. Setting: Tertiary infertility practice. Patients: Seventy-eight women for 80 cycles began LA on day 1 of their menstrual cycle. After 11 days of LA, 47 (59%) cycles in group I had suppressed serum estradiol (E2) levels <40 pg/mL, in contrast to 33 (41%) cycles in group II not adequately suppressed, thereby requiring additional days to achieve suppression. Interventions: Controlled ovarian hyperstimulation was started when patients were satisfactorily suppressed, i.e., E2 <40 pg/mL. Main Outcome Measure(s): Mean E2 response, ampules of human menopausal gonadotropin, cancellation rates, number of oocytes retrieved, fertilization rates, and pregnancy rates (PRs) per cycle were examined between groups I and II. Results: Group I demonstrated a greater mean E2 response on the day of human chorionic gonadotropin 1,735 pg/mL versus 1,470 pg/mL (P = 0.008), a greater fertilization rate 64% versus 55% (P = 0.02), and a higher PR per cycle 34% versus 12% (P = 0.036) compared with group II. Conclusions: Women who achieved desensitization-suppression within 11 days of initiating LA demonstrated a more favorable outcome for IVF-ET than those who did not.

AB - Objective: To determine if the timing of the onset of pituitary desensitization and ovarian suppression using follicular phase leuprolide acetate (LA) is associated with in vitro fertilization-embryo transfer (IVF-ET) success for pregnancy. Design: Retrospective series of IVF patients undergoing pituitary desensitization and ovarian suppression before beginning controlled ovarian hyperstimulation for IVF-ET. Setting: Tertiary infertility practice. Patients: Seventy-eight women for 80 cycles began LA on day 1 of their menstrual cycle. After 11 days of LA, 47 (59%) cycles in group I had suppressed serum estradiol (E2) levels <40 pg/mL, in contrast to 33 (41%) cycles in group II not adequately suppressed, thereby requiring additional days to achieve suppression. Interventions: Controlled ovarian hyperstimulation was started when patients were satisfactorily suppressed, i.e., E2 <40 pg/mL. Main Outcome Measure(s): Mean E2 response, ampules of human menopausal gonadotropin, cancellation rates, number of oocytes retrieved, fertilization rates, and pregnancy rates (PRs) per cycle were examined between groups I and II. Results: Group I demonstrated a greater mean E2 response on the day of human chorionic gonadotropin 1,735 pg/mL versus 1,470 pg/mL (P = 0.008), a greater fertilization rate 64% versus 55% (P = 0.02), and a higher PR per cycle 34% versus 12% (P = 0.036) compared with group II. Conclusions: Women who achieved desensitization-suppression within 11 days of initiating LA demonstrated a more favorable outcome for IVF-ET than those who did not.

UR - http://www.scopus.com/inward/record.url?scp=0025995561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025995561&partnerID=8YFLogxK

M3 - Article

C2 - 1909977

AN - SCOPUS:0025995561

VL - 56

SP - 500

EP - 504

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 3

ER -