Early onset of puberty: Tracking genetic and environmental factors

Anne Simone Parent, Gregory Rasier, Arlette Gerard, Sabine Heger, Christian Roth, Claudio Mastronardi, Heike Jung, Sergio Ojeda, Jean Pierre Bourguignon

    Research output: Contribution to journalArticle

    51 Citations (Scopus)

    Abstract

    Under physiological conditions, factors affecting the genetic control of hypothalamic functions are predominant in determining the individual variations in timing of pubertal onset. In pathological conditions, however, these variations can involve different genetic susceptibility and the interaction of environmental factors. The high incidence of precocious puberty in foreign children migrating to Belgium and the detection in their plasma of a long-lasting 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT) residue suggest the potential role of environmental endocrine disrupting chemicals in the early onset of puberty. This hypothesis was confirmed by experimental data showing that temporary exposure of immature female rats to DDT in vivo results in early onset of puberty. We compared the gene expression profile of hypothalamic hamartoma associated or not with precocious puberty in order to identify gene networks responsible for both hamartoma-dependent sexual precocity and the onset of normal human puberty. In conclusion, pathological variations in the timing of puberty may provide unique information about the interactions of either environmental conditions or genetic susceptibility with the hypothalamic mechanism controlling the onset of sexual maturation, as shown by examples of precocious puberty following exposure to endocrine disrupters or due to hypothalamic hamartoma.

    Original languageEnglish (US)
    Pages (from-to)41-47
    Number of pages7
    JournalHormone Research
    Volume64
    Issue numberSUPPL. 2
    DOIs
    StatePublished - Nov 2005

    Fingerprint

    Puberty
    Precocious Puberty
    DDT
    Genetic Predisposition to Disease
    Endocrine Disruptors
    Sexual Maturation
    Ethane
    Hamartoma
    Gene Regulatory Networks
    Belgium
    Transcriptome
    Incidence
    Hypothalamic hamartomas

    Keywords

    • Dichlorodiphenyltrichloroethane (DDT)
    • Endocrine disrupting chemicals
    • Gonadotropin releasing hormone
    • Hypothalamic hamartoma
    • Secular trend

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Parent, A. S., Rasier, G., Gerard, A., Heger, S., Roth, C., Mastronardi, C., ... Bourguignon, J. P. (2005). Early onset of puberty: Tracking genetic and environmental factors. Hormone Research, 64(SUPPL. 2), 41-47. https://doi.org/10.1159/000087753

    Early onset of puberty : Tracking genetic and environmental factors. / Parent, Anne Simone; Rasier, Gregory; Gerard, Arlette; Heger, Sabine; Roth, Christian; Mastronardi, Claudio; Jung, Heike; Ojeda, Sergio; Bourguignon, Jean Pierre.

    In: Hormone Research, Vol. 64, No. SUPPL. 2, 11.2005, p. 41-47.

    Research output: Contribution to journalArticle

    Parent, AS, Rasier, G, Gerard, A, Heger, S, Roth, C, Mastronardi, C, Jung, H, Ojeda, S & Bourguignon, JP 2005, 'Early onset of puberty: Tracking genetic and environmental factors', Hormone Research, vol. 64, no. SUPPL. 2, pp. 41-47. https://doi.org/10.1159/000087753
    Parent AS, Rasier G, Gerard A, Heger S, Roth C, Mastronardi C et al. Early onset of puberty: Tracking genetic and environmental factors. Hormone Research. 2005 Nov;64(SUPPL. 2):41-47. https://doi.org/10.1159/000087753
    Parent, Anne Simone ; Rasier, Gregory ; Gerard, Arlette ; Heger, Sabine ; Roth, Christian ; Mastronardi, Claudio ; Jung, Heike ; Ojeda, Sergio ; Bourguignon, Jean Pierre. / Early onset of puberty : Tracking genetic and environmental factors. In: Hormone Research. 2005 ; Vol. 64, No. SUPPL. 2. pp. 41-47.
    @article{75d3a0dfea12410cb3f06908ba62afd9,
    title = "Early onset of puberty: Tracking genetic and environmental factors",
    abstract = "Under physiological conditions, factors affecting the genetic control of hypothalamic functions are predominant in determining the individual variations in timing of pubertal onset. In pathological conditions, however, these variations can involve different genetic susceptibility and the interaction of environmental factors. The high incidence of precocious puberty in foreign children migrating to Belgium and the detection in their plasma of a long-lasting 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT) residue suggest the potential role of environmental endocrine disrupting chemicals in the early onset of puberty. This hypothesis was confirmed by experimental data showing that temporary exposure of immature female rats to DDT in vivo results in early onset of puberty. We compared the gene expression profile of hypothalamic hamartoma associated or not with precocious puberty in order to identify gene networks responsible for both hamartoma-dependent sexual precocity and the onset of normal human puberty. In conclusion, pathological variations in the timing of puberty may provide unique information about the interactions of either environmental conditions or genetic susceptibility with the hypothalamic mechanism controlling the onset of sexual maturation, as shown by examples of precocious puberty following exposure to endocrine disrupters or due to hypothalamic hamartoma.",
    keywords = "Dichlorodiphenyltrichloroethane (DDT), Endocrine disrupting chemicals, Gonadotropin releasing hormone, Hypothalamic hamartoma, Secular trend",
    author = "Parent, {Anne Simone} and Gregory Rasier and Arlette Gerard and Sabine Heger and Christian Roth and Claudio Mastronardi and Heike Jung and Sergio Ojeda and Bourguignon, {Jean Pierre}",
    year = "2005",
    month = "11",
    doi = "10.1159/000087753",
    language = "English (US)",
    volume = "64",
    pages = "41--47",
    journal = "Hormone Research in Paediatrics",
    issn = "1663-2818",
    publisher = "S. Karger AG",
    number = "SUPPL. 2",

    }

    TY - JOUR

    T1 - Early onset of puberty

    T2 - Tracking genetic and environmental factors

    AU - Parent, Anne Simone

    AU - Rasier, Gregory

    AU - Gerard, Arlette

    AU - Heger, Sabine

    AU - Roth, Christian

    AU - Mastronardi, Claudio

    AU - Jung, Heike

    AU - Ojeda, Sergio

    AU - Bourguignon, Jean Pierre

    PY - 2005/11

    Y1 - 2005/11

    N2 - Under physiological conditions, factors affecting the genetic control of hypothalamic functions are predominant in determining the individual variations in timing of pubertal onset. In pathological conditions, however, these variations can involve different genetic susceptibility and the interaction of environmental factors. The high incidence of precocious puberty in foreign children migrating to Belgium and the detection in their plasma of a long-lasting 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT) residue suggest the potential role of environmental endocrine disrupting chemicals in the early onset of puberty. This hypothesis was confirmed by experimental data showing that temporary exposure of immature female rats to DDT in vivo results in early onset of puberty. We compared the gene expression profile of hypothalamic hamartoma associated or not with precocious puberty in order to identify gene networks responsible for both hamartoma-dependent sexual precocity and the onset of normal human puberty. In conclusion, pathological variations in the timing of puberty may provide unique information about the interactions of either environmental conditions or genetic susceptibility with the hypothalamic mechanism controlling the onset of sexual maturation, as shown by examples of precocious puberty following exposure to endocrine disrupters or due to hypothalamic hamartoma.

    AB - Under physiological conditions, factors affecting the genetic control of hypothalamic functions are predominant in determining the individual variations in timing of pubertal onset. In pathological conditions, however, these variations can involve different genetic susceptibility and the interaction of environmental factors. The high incidence of precocious puberty in foreign children migrating to Belgium and the detection in their plasma of a long-lasting 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT) residue suggest the potential role of environmental endocrine disrupting chemicals in the early onset of puberty. This hypothesis was confirmed by experimental data showing that temporary exposure of immature female rats to DDT in vivo results in early onset of puberty. We compared the gene expression profile of hypothalamic hamartoma associated or not with precocious puberty in order to identify gene networks responsible for both hamartoma-dependent sexual precocity and the onset of normal human puberty. In conclusion, pathological variations in the timing of puberty may provide unique information about the interactions of either environmental conditions or genetic susceptibility with the hypothalamic mechanism controlling the onset of sexual maturation, as shown by examples of precocious puberty following exposure to endocrine disrupters or due to hypothalamic hamartoma.

    KW - Dichlorodiphenyltrichloroethane (DDT)

    KW - Endocrine disrupting chemicals

    KW - Gonadotropin releasing hormone

    KW - Hypothalamic hamartoma

    KW - Secular trend

    UR - http://www.scopus.com/inward/record.url?scp=27944448944&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=27944448944&partnerID=8YFLogxK

    U2 - 10.1159/000087753

    DO - 10.1159/000087753

    M3 - Article

    C2 - 16286770

    AN - SCOPUS:27944448944

    VL - 64

    SP - 41

    EP - 47

    JO - Hormone Research in Paediatrics

    JF - Hormone Research in Paediatrics

    SN - 1663-2818

    IS - SUPPL. 2

    ER -