Early invasive cervical cancer: MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study

Donald G. Mitchell, Bradley Snyder, Fergus Coakley, Caroline Reinhold, Gillian Thomas, Marco A. Amendola, Lawrence H. Schwartz, Paula Woodward, Harpreet Pannu, Mostafa Atri, Hedvig Hricak

Research output: Contribution to journalArticle

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Abstract

Purpose: To compare MRI, CT, clinical exam and histopathological analysis for predicting lymph node involvement in women with cervical carcinoma, verified by lymphadenectomy. Methods: A 25-center ACRIN/GOG study enrolled 208 patients with biopsy-proven invasive cervical cancer for MRI and CT prior to attempted curative radical hysterectomy. Each imaging study was interpreted prospectively by one onsite radiologist, and retrospectively by 4 independent offsite radiologists, all blinded to surgical, histopathological and other imaging findings. Likelihood of parametrial and uterine body involvement was rated on a 5-point scale. Tumor size measurements were attempted in 3 axes. Association with histologic lymph node involvement, scored as absent, pelvic only and common iliac or paraaortic, was evaluated using Cochran-Mantel Haenszel statistics, univariate and multivariate logistic regression, generalized estimating equations, accuracy statistics and ROC analysis. Results: Lymphatic metastases were found in 34% of women; 13% had common iliac nodal metastases, and 9% had paraortic nodal metastases. Based on the retrospective multi-observer re-reads, the average AUC for predicting histologic lymph node involvement based on tumor size was higher for MRI versus CT, although formal statistic comparisons could not be conducted. Multivariate analysis showed improved model fit incorporating predictors from MRI, but not from CT, over and above the initial clinical and biopsy predictors, although the increase in discriminatory ability was not statistically significant. Conclusion: MRI findings may help predict the presence of histologic lymph node involvement in women with early invasive cervical carcinoma, thus providing important prognostic information.

Original languageEnglish (US)
Pages (from-to)95-103
Number of pages9
JournalGynecologic Oncology
Volume112
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

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Lymphatic Metastasis
Uterine Cervical Neoplasms
Lymph Nodes
Neoplasm Metastasis
Carcinoma
Biopsy
Lymph Node Excision
Hysterectomy
ROC Curve
Area Under Curve
Neoplasms
Multivariate Analysis
Logistic Models
Radiologists

Keywords

  • Cervical cancer
  • Computed tomography
  • FIGO
  • Imaging
  • Magnetic resonance imaging
  • Staging

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Early invasive cervical cancer : MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study. / Mitchell, Donald G.; Snyder, Bradley; Coakley, Fergus; Reinhold, Caroline; Thomas, Gillian; Amendola, Marco A.; Schwartz, Lawrence H.; Woodward, Paula; Pannu, Harpreet; Atri, Mostafa; Hricak, Hedvig.

In: Gynecologic Oncology, Vol. 112, No. 1, 01.2009, p. 95-103.

Research output: Contribution to journalArticle

Mitchell, DG, Snyder, B, Coakley, F, Reinhold, C, Thomas, G, Amendola, MA, Schwartz, LH, Woodward, P, Pannu, H, Atri, M & Hricak, H 2009, 'Early invasive cervical cancer: MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study', Gynecologic Oncology, vol. 112, no. 1, pp. 95-103. https://doi.org/10.1016/j.ygyno.2008.10.005
Mitchell, Donald G. ; Snyder, Bradley ; Coakley, Fergus ; Reinhold, Caroline ; Thomas, Gillian ; Amendola, Marco A. ; Schwartz, Lawrence H. ; Woodward, Paula ; Pannu, Harpreet ; Atri, Mostafa ; Hricak, Hedvig. / Early invasive cervical cancer : MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study. In: Gynecologic Oncology. 2009 ; Vol. 112, No. 1. pp. 95-103.
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AU - Thomas, Gillian

AU - Amendola, Marco A.

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