Early Diagnosis and Management of Aggressive Posterior Vitreoretinopathy Presenting in Premature Neonates

Mrinali P. Gupta, Yoshihiro Yonekawa, John Campbell, Irene Rusu, Sarwar Zahid, Samir N. Patel, Felix Chau, Karyn E. Jonas, Erica Oltra, Anton Orlin, Jonathan Chang, Jason Horowitz, David H. Abramson, Brian Marr, Antonio Capone, R. V. Paul Chan

Research output: Contribution to journalArticle


BACKGROUND AND OBJECTIVE: Aggressive posterior vitreoretinopathy (APVR) manifests with a broad area of retinal avascularity, progressive neovascularization, and/or tractional retinal detachment during the neonatal period. PATIENTS AND METHODS: A multicenter, retrospective, observational, consecutive case series study was performed to evaluate the retinal findings and structural retinal outcomes in patients treated for APVR within the first 3 months of life. RESULTS: Three premature neonates with a non-retinopathy of prematurity (ROP) APVR identified during routine ROP screening exams exhibited relatively severe, rapidly progressive retinal vascular abnormalities. Immediate laser photocoagulation of the avascular retina and vitrectomy for traction retinal detachment within several days to weeks improved or stabilized the retinal anatomy in all cases. CONCLUSIONS: This series describes clinical features in APVR in premature infants and suggests that early diagnosis and intervention may mitigate the typical aggressive course and poor prognosis of this condition. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:201-207.].

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalOphthalmic surgery, lasers & imaging retina
Issue number4
StatePublished - Apr 1 2019


ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Gupta, M. P., Yonekawa, Y., Campbell, J., Rusu, I., Zahid, S., Patel, S. N., Chau, F., Jonas, K. E., Oltra, E., Orlin, A., Chang, J., Horowitz, J., Abramson, D. H., Marr, B., Capone, A., & Paul Chan, R. V. (2019). Early Diagnosis and Management of Aggressive Posterior Vitreoretinopathy Presenting in Premature Neonates. Ophthalmic surgery, lasers & imaging retina, 50(4), 201-207. https://doi.org/10.3928/23258160-20190401-01