TY - JOUR
T1 - Early development of selenium-induced cataract
T2 - Slit lamp evaluation
AU - Shearer, T. R.
AU - Anderson, R. S.
AU - Britton, J. L.
AU - Palmer, E. A.
N1 - Funding Information:
support for this study was provided by NIH grant EY 3600 from the National and by the R. Blaine Bramble Medical Research Foundation.
PY - 1983/6
Y1 - 1983/6
N2 - The purpose of our research was to document early lenticular changes preceding cataract formation in rats receiving an elevated dose of selenium. The following stages were observed after selenium injection: Stage 1 (13-24 hr post-injection), formation of posterior equatorial subcapsular cataract (PESC); Stage 2 (24-72 hr), decline of the PESC, development of a prominent 'washer' shaped change in the refraction of the cortex, and first appearance of swollen fibers around the nucleus; Stage 3 (three to five days), appearance of bilateral dense central nuclear cataracts and further development of perinuclear swollen fibers; Stage 4 (five to 10 days), some nuclear cataracts became more opaque and/or angular. The results are consistent with the hypothesis that the initial site of action of selenium in nuclear cataract formation is not in the lens nucleus. Rather, selenium causes early changes outside the nucleus, which are followed by nuclear cataracts.
AB - The purpose of our research was to document early lenticular changes preceding cataract formation in rats receiving an elevated dose of selenium. The following stages were observed after selenium injection: Stage 1 (13-24 hr post-injection), formation of posterior equatorial subcapsular cataract (PESC); Stage 2 (24-72 hr), decline of the PESC, development of a prominent 'washer' shaped change in the refraction of the cortex, and first appearance of swollen fibers around the nucleus; Stage 3 (three to five days), appearance of bilateral dense central nuclear cataracts and further development of perinuclear swollen fibers; Stage 4 (five to 10 days), some nuclear cataracts became more opaque and/or angular. The results are consistent with the hypothesis that the initial site of action of selenium in nuclear cataract formation is not in the lens nucleus. Rather, selenium causes early changes outside the nucleus, which are followed by nuclear cataracts.
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U2 - 10.1016/0014-4835(83)90032-5
DO - 10.1016/0014-4835(83)90032-5
M3 - Article
C2 - 6861915
AN - SCOPUS:0020565576
SN - 0014-4835
VL - 36
SP - 781
EP - 788
JO - Experimental Eye Research
JF - Experimental Eye Research
IS - 6
ER -