Early detection of ototoxicity using high-frequency, tone-burst-evoked auditory brainstem responses.

S. A. Fausti, R. H. Frey, James Henry, D. J. Olson, H. I. Schaffer

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Subjects receiving treatment with ototoxic agents were evaluated concurrently with conventional and high-frequency (> or = 8 kHz) behavioral threshold measures and with ABR to click and to 8, 10, 12, and 14 kHz tone-burst stimuli. Behavioral threshold data revealed ototoxic change in 51 percent of ears evaluated. Of these ears demonstrating behavioral change, 90 percent revealed concurrent ABR changes. If only ABR monitoring with high-frequency tone-burst stimuli had been used, 87 percent of allears showing behavioral change would have been identified. Three fourths of these would have been identified from wave V responses, with 87 percent identified from the two highest frequencies tested for each individual. This research suggests that behavioral change is reflected accurately in the ABR, that high-frequency tone bursts will identify a majority of initial ototoxic changes, and that monitoring hearing with high-frequency, tone-burst-evoked ABRs during treatment with potentially ototoxic agents is significantly more effective than click-evoked ABRs for early detection of ototoxicity.

Original languageEnglish (US)
Pages (from-to)397-404
Number of pages8
JournalJournal of the American Academy of Audiology
Volume3
Issue number6
StatePublished - Nov 1992
Externally publishedYes

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Brain Stem Auditory Evoked Potentials
Ear
Behavioral Research
Hearing
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

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Early detection of ototoxicity using high-frequency, tone-burst-evoked auditory brainstem responses. / Fausti, S. A.; Frey, R. H.; Henry, James; Olson, D. J.; Schaffer, H. I.

In: Journal of the American Academy of Audiology, Vol. 3, No. 6, 11.1992, p. 397-404.

Research output: Contribution to journalArticle

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