Early detection of cancer

David Crosby; Sangeeta Bhatia; Kevin M. Brindle; Lisa M. Coussens; Caroline Dive; Mark Emberton; Sadik Esener; Rebecca C. Fitzgerald; Sanjiv S. Gambhir; Peter Kuhn; Timothy R. Rebbeck; Shankar Balasubramanian

doi:10.1126/science.aay9040

Early detection of cancer

David Crosby, Sangeeta Bhatia, Kevin M. Brindle, Lisa M. Coussens, Caroline Dive, Mark Emberton, Sadik Esener, Rebecca C. Fitzgerald, Sanjiv S. Gambhir, Peter Kuhn, Timothy R. Rebbeck, Shankar Balasubramanian

Research output: Contribution to journal › Review article › peer-review

246 Scopus citations

Abstract

Survival improves when cancer is detected early. However, ∼50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early intervention to try to slow or prevent cancer development and lethality. To achieve early detection of all cancers, numerous challenges must be overcome. It is vital to better understand who is at greatest risk of developing cancer. We also need to elucidate the biology and trajectory of precancer and early cancer to identify consequential disease that requires intervention. Insights must be translated into sensitive and specific early detection technologies and be appropriately evaluated to support practical clinical implementation. Interdisciplinary collaboration is key; advances in technology and biological understanding highlight that it is time to accelerate early detection research and transform cancer survival.

Original language	English (US)
Article number	aay9040
Journal	Science
Volume	375
Issue number	6586
DOIs	https://doi.org/10.1126/science.aay9040
State	Published - Mar 18 2022

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title = "Early detection of cancer",

abstract = "Survival improves when cancer is detected early. However, ∼50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early intervention to try to slow or prevent cancer development and lethality. To achieve early detection of all cancers, numerous challenges must be overcome. It is vital to better understand who is at greatest risk of developing cancer. We also need to elucidate the biology and trajectory of precancer and early cancer to identify consequential disease that requires intervention. Insights must be translated into sensitive and specific early detection technologies and be appropriately evaluated to support practical clinical implementation. Interdisciplinary collaboration is key; advances in technology and biological understanding highlight that it is time to accelerate early detection research and transform cancer survival.",

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AU - Crosby, David

AU - Bhatia, Sangeeta

AU - Brindle, Kevin M.

AU - Coussens, Lisa M.

AU - Dive, Caroline

AU - Emberton, Mark

AU - Esener, Sadik

AU - Fitzgerald, Rebecca C.

AU - Gambhir, Sanjiv S.

AU - Kuhn, Peter

AU - Rebbeck, Timothy R.

AU - Balasubramanian, Shankar

PY - 2022/3/18

Y1 - 2022/3/18

N2 - Survival improves when cancer is detected early. However, ∼50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early intervention to try to slow or prevent cancer development and lethality. To achieve early detection of all cancers, numerous challenges must be overcome. It is vital to better understand who is at greatest risk of developing cancer. We also need to elucidate the biology and trajectory of precancer and early cancer to identify consequential disease that requires intervention. Insights must be translated into sensitive and specific early detection technologies and be appropriately evaluated to support practical clinical implementation. Interdisciplinary collaboration is key; advances in technology and biological understanding highlight that it is time to accelerate early detection research and transform cancer survival.

AB - Survival improves when cancer is detected early. However, ∼50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early intervention to try to slow or prevent cancer development and lethality. To achieve early detection of all cancers, numerous challenges must be overcome. It is vital to better understand who is at greatest risk of developing cancer. We also need to elucidate the biology and trajectory of precancer and early cancer to identify consequential disease that requires intervention. Insights must be translated into sensitive and specific early detection technologies and be appropriately evaluated to support practical clinical implementation. Interdisciplinary collaboration is key; advances in technology and biological understanding highlight that it is time to accelerate early detection research and transform cancer survival.

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Early detection of cancer

Abstract

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