Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques

Megan A. O’Connor, Jennifer Tisoncik-Go, Thomas B. Lewis, Charlene J. Miller, Debra Bratt, Cassie R. Moats, Paul T. Edlefsen, Jeremy Smedley, Nichole R. Klatt, Michael Gale, Deborah Heydenburg Fuller

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The immunological and virological events that contribute to the establishment of Zika virus (ZIKV) infection in humans are unclear. Here, we show that robust cellular innate immune responses arising early in the blood and tissues in response to ZIKV infection are significantly stronger in males and correlate with increased viral persistence. In particular, early peripheral blood recruitment of plasmacytoid dendritic cells and higher production of monocyte chemoattractant protein (MCP-1) correspond with greater viral persistence and tissue dissemination. We also identify non-classical monocytes as primary in vivo targets of ZIKV infection in the blood and peripheral lymph node. These results demonstrate the potential differences in ZIKV pathogenesis between males and females and a key role for early cellular innate immune responses in the blood in viral dissemination and ZIKV pathogenesis.

Original languageEnglish (US)
Article number3371
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

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tropism
Macaca nemestrina
Tropism
viruses
Viruses
Innate Immunity
Cellular Immunity
blood
Tissue
infectious diseases
Blood
monocytes
pathogenesis
Monocyte Chemoattractant Proteins
Chemokine CCL2
Dendritic Cells
lymphatic system
Monocytes
Lymph Nodes
proteins

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

O’Connor, M. A., Tisoncik-Go, J., Lewis, T. B., Miller, C. J., Bratt, D., Moats, C. R., ... Fuller, D. H. (2018). Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques. Nature Communications, 9(1), [3371]. https://doi.org/10.1038/s41467-018-05826-w

Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques. / O’Connor, Megan A.; Tisoncik-Go, Jennifer; Lewis, Thomas B.; Miller, Charlene J.; Bratt, Debra; Moats, Cassie R.; Edlefsen, Paul T.; Smedley, Jeremy; Klatt, Nichole R.; Gale, Michael; Fuller, Deborah Heydenburg.

In: Nature Communications, Vol. 9, No. 1, 3371, 01.12.2018.

Research output: Contribution to journalArticle

O’Connor, MA, Tisoncik-Go, J, Lewis, TB, Miller, CJ, Bratt, D, Moats, CR, Edlefsen, PT, Smedley, J, Klatt, NR, Gale, M & Fuller, DH 2018, 'Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques', Nature Communications, vol. 9, no. 1, 3371. https://doi.org/10.1038/s41467-018-05826-w
O’Connor, Megan A. ; Tisoncik-Go, Jennifer ; Lewis, Thomas B. ; Miller, Charlene J. ; Bratt, Debra ; Moats, Cassie R. ; Edlefsen, Paul T. ; Smedley, Jeremy ; Klatt, Nichole R. ; Gale, Michael ; Fuller, Deborah Heydenburg. / Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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