Early and late presentation of the ovarian hyperstimulation syndrome: Two distinct entities with different risk factors

C. A. Dahl Lyons, C. A. Wheeler, G. N. Frishman, R. J. Hackett, David Seifer, R. V. Haning

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

This study was designed to identify clinical predictors for early and late ovarian hyperstimulation syndrome (OHSS). A retrospective analysis of all 592 in-vitro fertilization (IVF) cycles from the programme's inception in 1988 up to March 1993 was performed. Six patients (1.0% of cycles) had moderate or severe OHSS presenting 3-7 days post-human chorionic gonadotrophin (HCG), and four patients (0.7% of cycles) had severe OHSS presenting 12-17 days post-HCG. No patient with early OHSS went on to develop late OHSS, and no patient with late OHSS had demonstrated early OHSS. Stepwise logistic regression showed that early OHSS was predicted by the number of oocytes retrieved (range 18-46) (P = 0.0001) and the oestradiol concentration on the day HCG was given (range 12 122-24 454 pmol/l) (P = 0.0003). Late OHSS was predicted by the number of gestational sacs (range 2-3) on ultrasound 4 weeks after embryo transfer (P = 0.0001) but not by the number of oocytes or oestradiol. Early OHSS was an acute effect of the HCG administered prior to egg retrieval in women with high oestradiol and larger numbers of follicles (range 22-51). Late OHSS was induced by the rising serum concentration of HCG produced by the early pregnancy, and in this series of cases it was associated only with multiple gestation.

Original languageEnglish (US)
Pages (from-to)792-799
Number of pages8
JournalHuman Reproduction
Volume9
Issue number5
StatePublished - 1994
Externally publishedYes

Fingerprint

Ovarian Hyperstimulation Syndrome
Chorionic Gonadotropin
Estradiol
Oocytes
Gestational Sac
Pregnancy
Embryo Transfer
Fertilization in Vitro
Ovum
Logistic Models

Keywords

  • HCG
  • IVF
  • Multiple gestation
  • OHSS
  • Prediction

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Dahl Lyons, C. A., Wheeler, C. A., Frishman, G. N., Hackett, R. J., Seifer, D., & Haning, R. V. (1994). Early and late presentation of the ovarian hyperstimulation syndrome: Two distinct entities with different risk factors. Human Reproduction, 9(5), 792-799.

Early and late presentation of the ovarian hyperstimulation syndrome : Two distinct entities with different risk factors. / Dahl Lyons, C. A.; Wheeler, C. A.; Frishman, G. N.; Hackett, R. J.; Seifer, David; Haning, R. V.

In: Human Reproduction, Vol. 9, No. 5, 1994, p. 792-799.

Research output: Contribution to journalArticle

Dahl Lyons, CA, Wheeler, CA, Frishman, GN, Hackett, RJ, Seifer, D & Haning, RV 1994, 'Early and late presentation of the ovarian hyperstimulation syndrome: Two distinct entities with different risk factors', Human Reproduction, vol. 9, no. 5, pp. 792-799.
Dahl Lyons CA, Wheeler CA, Frishman GN, Hackett RJ, Seifer D, Haning RV. Early and late presentation of the ovarian hyperstimulation syndrome: Two distinct entities with different risk factors. Human Reproduction. 1994;9(5):792-799.
Dahl Lyons, C. A. ; Wheeler, C. A. ; Frishman, G. N. ; Hackett, R. J. ; Seifer, David ; Haning, R. V. / Early and late presentation of the ovarian hyperstimulation syndrome : Two distinct entities with different risk factors. In: Human Reproduction. 1994 ; Vol. 9, No. 5. pp. 792-799.
@article{90e4a2d663ee430895ffd3b5c0193cff,
title = "Early and late presentation of the ovarian hyperstimulation syndrome: Two distinct entities with different risk factors",
abstract = "This study was designed to identify clinical predictors for early and late ovarian hyperstimulation syndrome (OHSS). A retrospective analysis of all 592 in-vitro fertilization (IVF) cycles from the programme's inception in 1988 up to March 1993 was performed. Six patients (1.0{\%} of cycles) had moderate or severe OHSS presenting 3-7 days post-human chorionic gonadotrophin (HCG), and four patients (0.7{\%} of cycles) had severe OHSS presenting 12-17 days post-HCG. No patient with early OHSS went on to develop late OHSS, and no patient with late OHSS had demonstrated early OHSS. Stepwise logistic regression showed that early OHSS was predicted by the number of oocytes retrieved (range 18-46) (P = 0.0001) and the oestradiol concentration on the day HCG was given (range 12 122-24 454 pmol/l) (P = 0.0003). Late OHSS was predicted by the number of gestational sacs (range 2-3) on ultrasound 4 weeks after embryo transfer (P = 0.0001) but not by the number of oocytes or oestradiol. Early OHSS was an acute effect of the HCG administered prior to egg retrieval in women with high oestradiol and larger numbers of follicles (range 22-51). Late OHSS was induced by the rising serum concentration of HCG produced by the early pregnancy, and in this series of cases it was associated only with multiple gestation.",
keywords = "HCG, IVF, Multiple gestation, OHSS, Prediction",
author = "{Dahl Lyons}, {C. A.} and Wheeler, {C. A.} and Frishman, {G. N.} and Hackett, {R. J.} and David Seifer and Haning, {R. V.}",
year = "1994",
language = "English (US)",
volume = "9",
pages = "792--799",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Early and late presentation of the ovarian hyperstimulation syndrome

T2 - Two distinct entities with different risk factors

AU - Dahl Lyons, C. A.

AU - Wheeler, C. A.

AU - Frishman, G. N.

AU - Hackett, R. J.

AU - Seifer, David

AU - Haning, R. V.

PY - 1994

Y1 - 1994

N2 - This study was designed to identify clinical predictors for early and late ovarian hyperstimulation syndrome (OHSS). A retrospective analysis of all 592 in-vitro fertilization (IVF) cycles from the programme's inception in 1988 up to March 1993 was performed. Six patients (1.0% of cycles) had moderate or severe OHSS presenting 3-7 days post-human chorionic gonadotrophin (HCG), and four patients (0.7% of cycles) had severe OHSS presenting 12-17 days post-HCG. No patient with early OHSS went on to develop late OHSS, and no patient with late OHSS had demonstrated early OHSS. Stepwise logistic regression showed that early OHSS was predicted by the number of oocytes retrieved (range 18-46) (P = 0.0001) and the oestradiol concentration on the day HCG was given (range 12 122-24 454 pmol/l) (P = 0.0003). Late OHSS was predicted by the number of gestational sacs (range 2-3) on ultrasound 4 weeks after embryo transfer (P = 0.0001) but not by the number of oocytes or oestradiol. Early OHSS was an acute effect of the HCG administered prior to egg retrieval in women with high oestradiol and larger numbers of follicles (range 22-51). Late OHSS was induced by the rising serum concentration of HCG produced by the early pregnancy, and in this series of cases it was associated only with multiple gestation.

AB - This study was designed to identify clinical predictors for early and late ovarian hyperstimulation syndrome (OHSS). A retrospective analysis of all 592 in-vitro fertilization (IVF) cycles from the programme's inception in 1988 up to March 1993 was performed. Six patients (1.0% of cycles) had moderate or severe OHSS presenting 3-7 days post-human chorionic gonadotrophin (HCG), and four patients (0.7% of cycles) had severe OHSS presenting 12-17 days post-HCG. No patient with early OHSS went on to develop late OHSS, and no patient with late OHSS had demonstrated early OHSS. Stepwise logistic regression showed that early OHSS was predicted by the number of oocytes retrieved (range 18-46) (P = 0.0001) and the oestradiol concentration on the day HCG was given (range 12 122-24 454 pmol/l) (P = 0.0003). Late OHSS was predicted by the number of gestational sacs (range 2-3) on ultrasound 4 weeks after embryo transfer (P = 0.0001) but not by the number of oocytes or oestradiol. Early OHSS was an acute effect of the HCG administered prior to egg retrieval in women with high oestradiol and larger numbers of follicles (range 22-51). Late OHSS was induced by the rising serum concentration of HCG produced by the early pregnancy, and in this series of cases it was associated only with multiple gestation.

KW - HCG

KW - IVF

KW - Multiple gestation

KW - OHSS

KW - Prediction

UR - http://www.scopus.com/inward/record.url?scp=0028283354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028283354&partnerID=8YFLogxK

M3 - Article

C2 - 7929724

AN - SCOPUS:0028283354

VL - 9

SP - 792

EP - 799

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 5

ER -