E-selectin is present in proliferating endothelial cells in human hemangiomas

Birgit M. Kräling, Maria Josephine Razon, Laurence M. Boon, David Zurakowski, Carrie Seachord, Richard P. Darveau, John B. Mulliken, Christopher Corless, Joyce Bischoff

Research output: Contribution to journalArticle

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Abstract

E-selectin, an endothelial-cell-specific leukocyte adhesion molecule, may also function in angiogenesis. To investigate its role in a noninflammatory angiogenic disease, E-selectin was analyzed by immunohistochemistry in specimens of proliferative phase and involutive phase hemangiomas. Hemangioma is an endothelial cell tumor of capillary blood vessels that grows rapidly during infancy and regresses spontaneously during childhood. E-selectin expression was high in proliferative phase specimens and was co-localized with dividing microvascular endothelial cells. Relative to the number of blood vessels, E-selectin declined significantly in involutive phase specimens demonstrating that E-selectin correlates with angiogenesis in the tumors. E-selectin was not detected in quiescent endothelium but was co- localized in dividing microvascular endothelial cells in placenta and neonatal foreskin, two tissues with ongoing growth of microvessels. These in vivo studies support the hypothesis that E-selectin functions in angiogenesis and suggest that E-selectin may be a marker for proliferating endothelium.

Original languageEnglish (US)
Pages (from-to)1181-1191
Number of pages11
JournalAmerican Journal of Pathology
Volume148
Issue number4
StatePublished - Apr 1996
Externally publishedYes

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E-Selectin
Hemangioma
Endothelial Cells
Endothelium
Vascular Tissue Neoplasms
Foreskin
Cell Adhesion Molecules
Microvessels
Placenta
Blood Vessels
Immunohistochemistry
Growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kräling, B. M., Razon, M. J., Boon, L. M., Zurakowski, D., Seachord, C., Darveau, R. P., ... Bischoff, J. (1996). E-selectin is present in proliferating endothelial cells in human hemangiomas. American Journal of Pathology, 148(4), 1181-1191.

E-selectin is present in proliferating endothelial cells in human hemangiomas. / Kräling, Birgit M.; Razon, Maria Josephine; Boon, Laurence M.; Zurakowski, David; Seachord, Carrie; Darveau, Richard P.; Mulliken, John B.; Corless, Christopher; Bischoff, Joyce.

In: American Journal of Pathology, Vol. 148, No. 4, 04.1996, p. 1181-1191.

Research output: Contribution to journalArticle

Kräling, BM, Razon, MJ, Boon, LM, Zurakowski, D, Seachord, C, Darveau, RP, Mulliken, JB, Corless, C & Bischoff, J 1996, 'E-selectin is present in proliferating endothelial cells in human hemangiomas', American Journal of Pathology, vol. 148, no. 4, pp. 1181-1191.
Kräling BM, Razon MJ, Boon LM, Zurakowski D, Seachord C, Darveau RP et al. E-selectin is present in proliferating endothelial cells in human hemangiomas. American Journal of Pathology. 1996 Apr;148(4):1181-1191.
Kräling, Birgit M. ; Razon, Maria Josephine ; Boon, Laurence M. ; Zurakowski, David ; Seachord, Carrie ; Darveau, Richard P. ; Mulliken, John B. ; Corless, Christopher ; Bischoff, Joyce. / E-selectin is present in proliferating endothelial cells in human hemangiomas. In: American Journal of Pathology. 1996 ; Vol. 148, No. 4. pp. 1181-1191.
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