Abstract
Recent data indicate that cortical dopamine denervation results in dystrophic changes in the dendrites of pyramidal cells, including decreases in dendritic spine density and length. However, it is not known if the loss of signaling through specific dopamine receptors subserves these dendritic changes. We examined the dendritic structure of layer V pyramidal cells in the prefrontal cortex of D1, D2, and D4 dopamine receptor null mutant mice and their wild-type littermates. Decreased basal dendritic length and spine density were observed in the D1 knockout mice. Similarly, a decrease in basal dendritic spine density was uncovered in the D2 knockout mice relative to wild-type littermates. No changes in any dendritic parameter were observed in the D4 knockout mice. These observations suggest that the dystrophic changes observed in prefrontal cortical pyramidal cell dendrites are due to loss of signaling through D1 and possibly D2 receptors. The current data also suggest that caution should be exercised in the interpretation of behavioral, physiological, and biochemical studies of the prefrontal cortex in dopamine receptor knockout mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 58-64 |
| Number of pages | 7 |
| Journal | Brain Research |
| Volume | 1300 |
| DOIs | |
| State | Published - Nov 10 2009 |
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Keywords
- Dendritic spine
- Dopamine receptor
- Golgi impregnation
- Parkinson's disease
- Pyramidal cell
- Schizophrenia
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Developmental Biology
- Molecular Biology
Cite this
Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice. / Wang, Hui Dong; Stanwood, Gregg D.; Grandy, David; Deutch, Ariel Y.
In: Brain Research, Vol. 1300, 10.11.2009, p. 58-64.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice
AU - Wang, Hui Dong
AU - Stanwood, Gregg D.
AU - Grandy, David
AU - Deutch, Ariel Y.
PY - 2009/11/10
Y1 - 2009/11/10
N2 - Recent data indicate that cortical dopamine denervation results in dystrophic changes in the dendrites of pyramidal cells, including decreases in dendritic spine density and length. However, it is not known if the loss of signaling through specific dopamine receptors subserves these dendritic changes. We examined the dendritic structure of layer V pyramidal cells in the prefrontal cortex of D1, D2, and D4 dopamine receptor null mutant mice and their wild-type littermates. Decreased basal dendritic length and spine density were observed in the D1 knockout mice. Similarly, a decrease in basal dendritic spine density was uncovered in the D2 knockout mice relative to wild-type littermates. No changes in any dendritic parameter were observed in the D4 knockout mice. These observations suggest that the dystrophic changes observed in prefrontal cortical pyramidal cell dendrites are due to loss of signaling through D1 and possibly D2 receptors. The current data also suggest that caution should be exercised in the interpretation of behavioral, physiological, and biochemical studies of the prefrontal cortex in dopamine receptor knockout mice.
AB - Recent data indicate that cortical dopamine denervation results in dystrophic changes in the dendrites of pyramidal cells, including decreases in dendritic spine density and length. However, it is not known if the loss of signaling through specific dopamine receptors subserves these dendritic changes. We examined the dendritic structure of layer V pyramidal cells in the prefrontal cortex of D1, D2, and D4 dopamine receptor null mutant mice and their wild-type littermates. Decreased basal dendritic length and spine density were observed in the D1 knockout mice. Similarly, a decrease in basal dendritic spine density was uncovered in the D2 knockout mice relative to wild-type littermates. No changes in any dendritic parameter were observed in the D4 knockout mice. These observations suggest that the dystrophic changes observed in prefrontal cortical pyramidal cell dendrites are due to loss of signaling through D1 and possibly D2 receptors. The current data also suggest that caution should be exercised in the interpretation of behavioral, physiological, and biochemical studies of the prefrontal cortex in dopamine receptor knockout mice.
KW - Dendritic spine
KW - Dopamine receptor
KW - Golgi impregnation
KW - Parkinson's disease
KW - Pyramidal cell
KW - Schizophrenia
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UR - http://www.scopus.com/inward/citedby.url?scp=73949106578&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2009.09.008
DO - 10.1016/j.brainres.2009.09.008
M3 - Article
C2 - 19747903
AN - SCOPUS:73949106578
VL - 1300
SP - 58
EP - 64
JO - Brain Research
JF - Brain Research
SN - 0006-8993
ER -