Dystroglycan is a scaffold for extracellular axon guidance decisions

L. Bailey Lindenmaier, Nicolas Parmentier, Caiying Guo, Fadel Tissir, Kevin Wright

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear. Here we show that the transmembrane glycoprotein Dystroglycan interacts with a changing set of environmental cues that regulate the trajectories of extending axons throughout the mammalian brain and spinal cord. Dystroglycan operates primarily as an extracellular scaffold during axon guidance, as it functions non-cell autonomously and does not require signaling through its intracellular domain. We identify the transmembrane receptor Celsr3/Adgrc3 as a binding partner for Dystroglycan, and show that this interaction is critical for specific axon guidance events in vivo. These findings establish Dystroglycan as a multifunctional scaffold that coordinates extracellular matrix proteins, secreted cues, and transmembrane receptors to regulate axon guidance.

Original languageEnglish (US)
JournaleLife
Volume8
DOIs
StatePublished - Feb 13 2019

Fingerprint

Dystroglycans
Scaffolds
Cues
Extracellular Matrix Proteins
Axons
Spinal Cord
Glycoproteins
Brain
Trajectories
Axon Guidance
Molecules

Keywords

  • axon guidance
  • celsr3
  • commissural axon
  • dystroglycan
  • extracellular matrix
  • internal capsule
  • mouse
  • neuroscience

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Dystroglycan is a scaffold for extracellular axon guidance decisions. / Lindenmaier, L. Bailey; Parmentier, Nicolas; Guo, Caiying; Tissir, Fadel; Wright, Kevin.

In: eLife, Vol. 8, 13.02.2019.

Research output: Contribution to journalArticle

Lindenmaier, L. Bailey ; Parmentier, Nicolas ; Guo, Caiying ; Tissir, Fadel ; Wright, Kevin. / Dystroglycan is a scaffold for extracellular axon guidance decisions. In: eLife. 2019 ; Vol. 8.
@article{fcd51702ef3148c5bfc5469369ae7b03,
title = "Dystroglycan is a scaffold for extracellular axon guidance decisions",
abstract = "Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear. Here we show that the transmembrane glycoprotein Dystroglycan interacts with a changing set of environmental cues that regulate the trajectories of extending axons throughout the mammalian brain and spinal cord. Dystroglycan operates primarily as an extracellular scaffold during axon guidance, as it functions non-cell autonomously and does not require signaling through its intracellular domain. We identify the transmembrane receptor Celsr3/Adgrc3 as a binding partner for Dystroglycan, and show that this interaction is critical for specific axon guidance events in vivo. These findings establish Dystroglycan as a multifunctional scaffold that coordinates extracellular matrix proteins, secreted cues, and transmembrane receptors to regulate axon guidance.",
keywords = "axon guidance, celsr3, commissural axon, dystroglycan, extracellular matrix, internal capsule, mouse, neuroscience",
author = "Lindenmaier, {L. Bailey} and Nicolas Parmentier and Caiying Guo and Fadel Tissir and Kevin Wright",
year = "2019",
month = "2",
day = "13",
doi = "10.7554/eLife.42143",
language = "English (US)",
volume = "8",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

TY - JOUR

T1 - Dystroglycan is a scaffold for extracellular axon guidance decisions

AU - Lindenmaier, L. Bailey

AU - Parmentier, Nicolas

AU - Guo, Caiying

AU - Tissir, Fadel

AU - Wright, Kevin

PY - 2019/2/13

Y1 - 2019/2/13

N2 - Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear. Here we show that the transmembrane glycoprotein Dystroglycan interacts with a changing set of environmental cues that regulate the trajectories of extending axons throughout the mammalian brain and spinal cord. Dystroglycan operates primarily as an extracellular scaffold during axon guidance, as it functions non-cell autonomously and does not require signaling through its intracellular domain. We identify the transmembrane receptor Celsr3/Adgrc3 as a binding partner for Dystroglycan, and show that this interaction is critical for specific axon guidance events in vivo. These findings establish Dystroglycan as a multifunctional scaffold that coordinates extracellular matrix proteins, secreted cues, and transmembrane receptors to regulate axon guidance.

AB - Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear. Here we show that the transmembrane glycoprotein Dystroglycan interacts with a changing set of environmental cues that regulate the trajectories of extending axons throughout the mammalian brain and spinal cord. Dystroglycan operates primarily as an extracellular scaffold during axon guidance, as it functions non-cell autonomously and does not require signaling through its intracellular domain. We identify the transmembrane receptor Celsr3/Adgrc3 as a binding partner for Dystroglycan, and show that this interaction is critical for specific axon guidance events in vivo. These findings establish Dystroglycan as a multifunctional scaffold that coordinates extracellular matrix proteins, secreted cues, and transmembrane receptors to regulate axon guidance.

KW - axon guidance

KW - celsr3

KW - commissural axon

KW - dystroglycan

KW - extracellular matrix

KW - internal capsule

KW - mouse

KW - neuroscience

UR - http://www.scopus.com/inward/record.url?scp=85062422441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062422441&partnerID=8YFLogxK

U2 - 10.7554/eLife.42143

DO - 10.7554/eLife.42143

M3 - Article

VL - 8

JO - eLife

JF - eLife

SN - 2050-084X

ER -