Dynamics of antibody nuclease activity in blood of women during pregnancy and lactation

V. N. Buneva, A. N. Kudryavtseva, A. V. Gal'vita, V. V. Dubrovskaya, O. V. Khokhlova, I. A. Kalinina, V. A. Galenok, G. A. Nevinskij

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In human milk we previously found catalytic antibodies (abzymes) catalyzing hydrolysis of DNA, RNA, NMP, NDP, and NTP and also phosphorylation of proteins and lipids. In the present study we have analyzed nuclease activities of antibodies in blood of women during pregnancy and lactation. Blood of healthy male and female volunteers lacked catalytically active antibodies, whereas antibodies from blood of pregnant women hydrolyzed DNA and RNA and their relative activity varied over a wide range. Relative blood abzyme activities significantly increased after delivery and at the beginning of lactation. The highest abzyme activity was observed in blood of parturient women. Although the dynamics of changes in antibody DNase activity during pregnancy was rather individual for each woman, there was a common trend in the increase in antibody activity in the first and/or third trimester of the pregnancy. The DNase activity of IgG and IgM from blood of healthy pregnant women was 4-5 times less than that from pregnant women with pronounced autoimmune thyroiditis.

Original languageEnglish (US)
Pages (from-to)1088-1100
Number of pages13
JournalBiokhimiya
Volume68
Issue number8
StatePublished - Oct 30 2003

Keywords

  • Human milk and blood
  • Hydrolysis of DNA and RNA
  • Immunoglobulins
  • Natural abzymes
  • Pregnancy and lactation

ASJC Scopus subject areas

  • Chemistry(all)

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    Buneva, V. N., Kudryavtseva, A. N., Gal'vita, A. V., Dubrovskaya, V. V., Khokhlova, O. V., Kalinina, I. A., Galenok, V. A., & Nevinskij, G. A. (2003). Dynamics of antibody nuclease activity in blood of women during pregnancy and lactation. Biokhimiya, 68(8), 1088-1100.