Dynamics of Antibody Nuclease Activity in Blood of Women during Pregnancy and Lactation

V. N. Buneva, A. N. Kudryavtseva, A. V. Gal'vita, Viktoriya Dubrovskaya, O. V. Khokhlova, I. A. Kalinina, V. A. Galenok, G. A. Nevinsky

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In human milk we previously found catalytic antibodies (abzymes) catalyzing hydrolysis of DNA, RNA, NMP, NDP, and NTP and also phosphorylation of proteins and lipids. In the present study we have analyzed nuclease activities of antibodies in blood of women during pregnancy and lactation. Blood of healthy male and female volunteers lacked catalytically active antibodies, whereas antibodies from blood of pregnant women hydrolyzed DNA and RNA and their relative activity varied over a wide range. Relative blood abzyme activities significantly increased after delivery and at the beginning of lactation. The highest abzyme activity was observed in blood of parturient women. Although the dynamics of changes in antibody DNase activity during pregnancy was rather individual for each woman, there was a common trend in the increase in antibody activity in the first and/or third trimester of the pregnancy. The DNase activity of IgG and IgM from blood of healthy pregnant women was 4-5 times less than that from pregnant women with pronounced autoimmune thyroiditis.

Original languageEnglish (US)
Pages (from-to)890-900
Number of pages11
JournalBiochemistry (Moscow)
Volume68
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Fingerprint

Lactation
Blood
Pregnancy
Antibodies
Pregnant Women
Deoxyribonucleases
Catalytic Antibodies
RNA
Autoimmune Thyroiditis
Phosphorylation
DNA
Third Pregnancy Trimester
Human Milk
First Pregnancy Trimester
Immunoglobulin M
Volunteers
Hydrolysis
Immunoglobulin G
Parturition
Lipids

Keywords

  • Human milk and blood
  • Hydrolysis of DNA and RNA
  • Immunoglobulins
  • Natural abzymes
  • Pregnancy and lactation

ASJC Scopus subject areas

  • Biochemistry

Cite this

Buneva, V. N., Kudryavtseva, A. N., Gal'vita, A. V., Dubrovskaya, V., Khokhlova, O. V., Kalinina, I. A., ... Nevinsky, G. A. (2003). Dynamics of Antibody Nuclease Activity in Blood of Women during Pregnancy and Lactation. Biochemistry (Moscow), 68(8), 890-900. https://doi.org/10.1023/A:1025703132523

Dynamics of Antibody Nuclease Activity in Blood of Women during Pregnancy and Lactation. / Buneva, V. N.; Kudryavtseva, A. N.; Gal'vita, A. V.; Dubrovskaya, Viktoriya; Khokhlova, O. V.; Kalinina, I. A.; Galenok, V. A.; Nevinsky, G. A.

In: Biochemistry (Moscow), Vol. 68, No. 8, 01.08.2003, p. 890-900.

Research output: Contribution to journalArticle

Buneva, VN, Kudryavtseva, AN, Gal'vita, AV, Dubrovskaya, V, Khokhlova, OV, Kalinina, IA, Galenok, VA & Nevinsky, GA 2003, 'Dynamics of Antibody Nuclease Activity in Blood of Women during Pregnancy and Lactation', Biochemistry (Moscow), vol. 68, no. 8, pp. 890-900. https://doi.org/10.1023/A:1025703132523
Buneva, V. N. ; Kudryavtseva, A. N. ; Gal'vita, A. V. ; Dubrovskaya, Viktoriya ; Khokhlova, O. V. ; Kalinina, I. A. ; Galenok, V. A. ; Nevinsky, G. A. / Dynamics of Antibody Nuclease Activity in Blood of Women during Pregnancy and Lactation. In: Biochemistry (Moscow). 2003 ; Vol. 68, No. 8. pp. 890-900.
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