Dynamic response of cochlear blood flow to occlusion of anterior inferior cerebellar artery in guinea pigs

Tianying Ren, G. B. Avinash, Alfred Nuttall, J. M. Miller, E. A. Laurikainen, W. S. Quirk

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

In this study we investigated the autoregulation and hemodynamics of cochlear blood flow (CBF) as measured by laser-Doppler flowmetry. When the anterior inferior cerebellar artery was clamped, CBF decreased ~40% (not to 'biological zero'), followed by a gradual increase. When the clamp was released, CBF quickly increased to as much as 167% of the baseline level and then slowly returned to baseline. We assume that the dynamic CBF response to anterior inferior cerebellar artery clamping reflects primarily a combination of passive elastic properties of the cochlear vessels and active autoregulatory mechanisms. The decrease portion of the negative phase and the increase portion of the positive phase reflect mainly passive behavior, static compliance, and resistance of vessels, whereas the slow exponential negative and positive changes indicate an active response of vessels: an autoregulatory mechanism based on compensatory vascular dilation and constriction. Our preliminary data show a very strong CBF autoregulatory response to a change in intravascular pressure. Sympathetic stimulation can enhance this autoregulation, and CO2 inhalation promotes compensatory dilation and inhibits compensatory vascular constriction.

Original languageEnglish (US)
Pages (from-to)212-217
Number of pages6
JournalJournal of Applied Physiology
Volume76
Issue number1
StatePublished - 1994
Externally publishedYes

Fingerprint

Cochlea
Guinea Pigs
Arteries
Constriction
Blood Vessels
Dilatation
Homeostasis
Laser-Doppler Flowmetry
Inhalation
Compliance
Hemodynamics
Pressure

Keywords

  • autoregulation
  • inner ear blood flow
  • inner ear hemodynamics
  • laser- Doppler flowmetry

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Dynamic response of cochlear blood flow to occlusion of anterior inferior cerebellar artery in guinea pigs. / Ren, Tianying; Avinash, G. B.; Nuttall, Alfred; Miller, J. M.; Laurikainen, E. A.; Quirk, W. S.

In: Journal of Applied Physiology, Vol. 76, No. 1, 1994, p. 212-217.

Research output: Contribution to journalArticle

Ren, Tianying ; Avinash, G. B. ; Nuttall, Alfred ; Miller, J. M. ; Laurikainen, E. A. ; Quirk, W. S. / Dynamic response of cochlear blood flow to occlusion of anterior inferior cerebellar artery in guinea pigs. In: Journal of Applied Physiology. 1994 ; Vol. 76, No. 1. pp. 212-217.
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