Dynamic gene expression in the song system of zebra finches during the song learning period

Christopher R. Olson, Lisa K. Hodges, Claudio Mello

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The brain circuitry that controls song learning and production undergoes marked changes in morphology and connectivity during the song learning period in juvenile zebra finches, in parallel to the acquisition, practice and refinement of song. Yet, the genetic programs and timing of regulatory change that establish the neuronal connectivity and plasticity during this critical learning period remain largely undetermined. To address this question, we used in situ hybridization to compare the expression patterns of a set of 30 known robust molecular markers of HVC and/or area X, major telencephalic song nuclei, between adult and juvenile male zebra finches at different ages during development (20, 35, 50 days post-hatch, dph). We found that several of the genes examined undergo substantial changes in expression within HVC or its surrounds, and/or in other song nuclei. They fit into broad patterns of regulation, including those whose expression within HVC during this period increases (COL12A1, COL 21A1, MPZL1, PVALB, and CXCR7) or decreases (e.g., KCNT2, SAP30L), as well as some that show decreased expression in the surrounding tissue with little change within song nuclei (e.g. SV2B, TAC1). These results reveal a broad range of molecular changes that occur in the song system in concert with the song learning period. Some of the genes and pathways identified are potential modulators of the developmental changes associated with the emergence of the adult properties of the song control system, and/or the acquisition of learned vocalizations in songbirds.

Original languageEnglish (US)
Pages (from-to)1315-1338
Number of pages24
JournalDevelopmental Neurobiology
Volume75
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Finches
Equidae
Music
Learning
Gene Expression
Telencephalon
Songbirds
Neuronal Plasticity
Genes
In Situ Hybridization

Keywords

  • Brain development
  • Gene expression
  • Song system
  • Vocal learning
  • Zebra finch

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

Dynamic gene expression in the song system of zebra finches during the song learning period. / Olson, Christopher R.; Hodges, Lisa K.; Mello, Claudio.

In: Developmental Neurobiology, Vol. 75, No. 12, 01.12.2015, p. 1315-1338.

Research output: Contribution to journalArticle

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