Dynamic-contrast-enhanced-MRI with extravasating contrast reagent

Rat cerebral glioma blood volume determination

Xin Li, William Rooney, Csanád G. Várallyay, Seymur Gahramanov, Leslie Muldoon, James A. Goodman, Ian J. Tagge, Audrey H. Selzer, Martin Pike, Edward Neuwelt, Charles Jr Springer

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The accurate mapping of the tumor blood volume (TBV) fraction (v b) is a highly desired imaging biometric goal. It is commonly thought that achieving this is difficult, if not impossible, when small molecule contrast reagents (CRs) are used for the T1-weighted (Dynamic-Contrast-Enhanced) DCE-MRI technique. This is because angiogenic malignant tumor vessels allow facile CR extravasation. Here, a three-site equilibrium water exchange model is applied to DCE-MRI data from the cerebrally-implanted rat brain U87 glioma, a tumor exhibiting rapid CR extravasation. Analyses of segments of the (and the entire) DCE data time-course with this "shutter-speed" pharmacokinetic model, which admits finite water exchange kinetics, allow TBV estimation from the first-pass segment. Pairwise parameter determinances were tested with grid searches of 2D parametric error surfaces. Tumor blood volume (vb), as well as ve (the extracellular, extravascular space volume fraction), and Ktrans (a CR extravasation rate measure) parametric maps are presented. The role of the Patlak Plot in DCE-MRI is also considered.

Original languageEnglish (US)
Pages (from-to)190-199
Number of pages10
JournalJournal of Magnetic Resonance
Volume206
Issue number2
DOIs
StatePublished - Oct 2010

Fingerprint

Blood Volume Determination
blood volume
Glioma
Magnetic resonance imaging
rats
reagents
Rats
Tumors
Blood
tumors
Blood Volume
Tumor Burden
Volume fraction
Water
Extracellular Space
biometrics
Pharmacokinetics
shutters
Biometrics
Neoplasms

Keywords

  • DCE-MRI
  • Patlak Plot
  • Pharmacokinetics
  • Shutter-speed
  • Water exchange

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Biochemistry
  • Biophysics
  • Condensed Matter Physics

Cite this

Dynamic-contrast-enhanced-MRI with extravasating contrast reagent : Rat cerebral glioma blood volume determination. / Li, Xin; Rooney, William; Várallyay, Csanád G.; Gahramanov, Seymur; Muldoon, Leslie; Goodman, James A.; Tagge, Ian J.; Selzer, Audrey H.; Pike, Martin; Neuwelt, Edward; Springer, Charles Jr.

In: Journal of Magnetic Resonance, Vol. 206, No. 2, 10.2010, p. 190-199.

Research output: Contribution to journalArticle

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