@article{7e8e0777fac440de84a057e255f94c23,
title = "Dynamic contrast-enhanced MRI detects acute radiotherapy-induced alterations in mandibular microvasculature: Prospective assessment of imaging biomarkers of normal tissue injury",
abstract = "Normal tissue toxicity is an important consideration in the continued development of more effective external beam radiotherapy (EBRT) regimens for head and neck tumors. The ability to detect EBRT-induced changes in mandibular bone vascularity represents a crucial step in decreasing potential toxicity. To date, no imaging modality has been shown to detect changes in bone vascularity in real time during treatment. Based on our institutional experience with multi-parametric MRI, we hypothesized that DCE-MRI can provide in-treatment information regarding EBRT-induced changes in mandibular vascularity. Thirty-two patients undergoing EBRT treatment for head and neck cancer were prospectively imaged prior to, mid-course, and following treatment. DCE-MRI scans were co-registered to dosimetric maps to correlate EBRT dose and change in mandibular bone vascularity as measured by K trans and V e. DCE-MRI was able to detect dose-dependent changes in both K trans and V e in a subset of patients. One patient who developed ORN during the study period demonstrated decreases in K trans and V e following treatment completion. We demonstrate, in a prospective imaging trial, that DCE-MRI can detect dose-dependent alterations in mandibular bone vascularity during chemoradiotherapy, providing biomarkers that are physiological correlates of acute of acute mandibular vascular injury and recovery temporal kinetics.",
author = "Sandulache, {Vlad C.} and Hobbs, {Brian P.} and Mohamed, {R. Abdallah S.} and Frank, {Steven J.} and Juhee Song and Yao Ding and Rachel Ger and Court, {Laurence E.} and Jayashree Kalpathy-Cramer and Hazle, {John D.} and Jihong Wang and Awan, {Musaddiq J.} and Rosenthal, {David I.} and Garden, {Adam S.} and Gunn, {G. Brandon} and Colen, {Rivka R.} and Nabil Elshafeey and Mohamed Elbanan and Hutcheson, {Katherine A.} and Lewin, {Jan S.} and Chambers, {Mark S.} and Hofstede, {Theresa M.} and Weber, {Randal S.} and Lai, {Stephen Y.} and Fuller, {Clifton D.}",
note = "Funding Information: The Netherlands for assistance and conceptual development of image post-processing workflow; direct quality assurance, calculation, and imagepost-processing of pharmacokinetic parameters. Dr. Fuller received/receives grant support from: the SWOG Hope Foundation Dr. Charles A. Coltman, Jr. Fellowship in Clinical Trials; the National Institutes of Health Paul Calabresi Clinical Oncology Award Program (K12 CA088084) and Clinician Scientist Loan Repayment Program (L30 CA136381-02); Elekta AB/MD Anderson Consortium; GE Medical Systems/MD Anderson Center for Advanced Biomedical Imaging In-Kind Award; the MD Anderson Center for Radiation Oncology Research, and an MD Anderson Institutional Research Grant Program Award. Dr. Lai receives grant support from Institutional Start-up Funds and the National Cancer Institute (R21 CA178450).",
year = "2016",
month = aug,
day = "8",
doi = "10.1038/srep29864",
language = "English (US)",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}