Dynamic contrast-enhanced MR imaging features of the normal central zone of the prostate

Barry Hansford, Ibrahim Karademir, Yahui Peng, Yulei Jiang, Gregory Karczmar, Stephen Thomas, Ambereen Yousuf, Tatjana Antic, Scott Eggener, Aytekin Oto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Rationale and Objectives: Evaluate qualitative dynamic contrast-enhanced magnetic resonance imaging (MRI) characteristics of normal central zone based on recently described central zone MRI features. Materials and Methods: Institutional review board-approved, Health Insurance Portability and Accountability Act compliant study, 59 patients with prostate cancer, histopathology proven to not involve central zone or prostate base, underwent endorectal MRI before prostatectomy. Two readers independently reviewed T2-weighted images and apparent diffusion coefficient (ADC) maps identifying normal central zone based on low signal intensity and location. Next, two readers drew bilateral central zone regions of interest on dynamic contrast-enhanced magnetic resonance images in consensus and independently recorded enhancement curve types as type 1 (progressive), type 2 (plateau), and type 3 (wash-out). Identification rates of normal central zone and enhancement curve type were recorded and compared for each reviewer. The institutional review board waiver was approved and granted 05/2010. Results: Central zone identified in 92%-93% of patients on T2-weighted images and 78%-88% on ADC maps without significant difference between identification rates (P=.63 and P=.15 and inter-reader agreement (κ) is 0.64 and 0.29, for T2-weighted images and ADC maps, respectively). All central zones were rated either curve type 1 or curve type 2 by both radiologists. No statistically significant difference between the two radiologists (P=.19) and inter-reader agreement was κ=0.37. Conclusions: Normal central zone demonstrates either type 1 (progressive) or type 2 (plateau) enhancement curves on dynamic contrast-enhanced MRI that can be potentially useful to differentiate central zone from prostate cancer that classically demonstrates a type 3 (wash-out) enhancement curve.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalAcademic radiology
Volume21
Issue number5
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Prostate
Magnetic Resonance Imaging
Research Ethics Committees
Prostatic Neoplasms
Health Insurance Portability and Accountability Act
Prostatectomy
Magnetic Resonance Spectroscopy
Radiologists

Keywords

  • Central zone
  • Dynamic contrast-enhanced magnetic resonance imaging
  • Prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Dynamic contrast-enhanced MR imaging features of the normal central zone of the prostate. / Hansford, Barry; Karademir, Ibrahim; Peng, Yahui; Jiang, Yulei; Karczmar, Gregory; Thomas, Stephen; Yousuf, Ambereen; Antic, Tatjana; Eggener, Scott; Oto, Aytekin.

In: Academic radiology, Vol. 21, No. 5, 01.01.2014, p. 569-577.

Research output: Contribution to journalArticle

Hansford, B, Karademir, I, Peng, Y, Jiang, Y, Karczmar, G, Thomas, S, Yousuf, A, Antic, T, Eggener, S & Oto, A 2014, 'Dynamic contrast-enhanced MR imaging features of the normal central zone of the prostate', Academic radiology, vol. 21, no. 5, pp. 569-577. https://doi.org/10.1016/j.acra.2014.01.013
Hansford, Barry ; Karademir, Ibrahim ; Peng, Yahui ; Jiang, Yulei ; Karczmar, Gregory ; Thomas, Stephen ; Yousuf, Ambereen ; Antic, Tatjana ; Eggener, Scott ; Oto, Aytekin. / Dynamic contrast-enhanced MR imaging features of the normal central zone of the prostate. In: Academic radiology. 2014 ; Vol. 21, No. 5. pp. 569-577.
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AU - Karademir, Ibrahim

AU - Peng, Yahui

AU - Jiang, Yulei

AU - Karczmar, Gregory

AU - Thomas, Stephen

AU - Yousuf, Ambereen

AU - Antic, Tatjana

AU - Eggener, Scott

AU - Oto, Aytekin

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N2 - Rationale and Objectives: Evaluate qualitative dynamic contrast-enhanced magnetic resonance imaging (MRI) characteristics of normal central zone based on recently described central zone MRI features. Materials and Methods: Institutional review board-approved, Health Insurance Portability and Accountability Act compliant study, 59 patients with prostate cancer, histopathology proven to not involve central zone or prostate base, underwent endorectal MRI before prostatectomy. Two readers independently reviewed T2-weighted images and apparent diffusion coefficient (ADC) maps identifying normal central zone based on low signal intensity and location. Next, two readers drew bilateral central zone regions of interest on dynamic contrast-enhanced magnetic resonance images in consensus and independently recorded enhancement curve types as type 1 (progressive), type 2 (plateau), and type 3 (wash-out). Identification rates of normal central zone and enhancement curve type were recorded and compared for each reviewer. The institutional review board waiver was approved and granted 05/2010. Results: Central zone identified in 92%-93% of patients on T2-weighted images and 78%-88% on ADC maps without significant difference between identification rates (P=.63 and P=.15 and inter-reader agreement (κ) is 0.64 and 0.29, for T2-weighted images and ADC maps, respectively). All central zones were rated either curve type 1 or curve type 2 by both radiologists. No statistically significant difference between the two radiologists (P=.19) and inter-reader agreement was κ=0.37. Conclusions: Normal central zone demonstrates either type 1 (progressive) or type 2 (plateau) enhancement curves on dynamic contrast-enhanced MRI that can be potentially useful to differentiate central zone from prostate cancer that classically demonstrates a type 3 (wash-out) enhancement curve.

AB - Rationale and Objectives: Evaluate qualitative dynamic contrast-enhanced magnetic resonance imaging (MRI) characteristics of normal central zone based on recently described central zone MRI features. Materials and Methods: Institutional review board-approved, Health Insurance Portability and Accountability Act compliant study, 59 patients with prostate cancer, histopathology proven to not involve central zone or prostate base, underwent endorectal MRI before prostatectomy. Two readers independently reviewed T2-weighted images and apparent diffusion coefficient (ADC) maps identifying normal central zone based on low signal intensity and location. Next, two readers drew bilateral central zone regions of interest on dynamic contrast-enhanced magnetic resonance images in consensus and independently recorded enhancement curve types as type 1 (progressive), type 2 (plateau), and type 3 (wash-out). Identification rates of normal central zone and enhancement curve type were recorded and compared for each reviewer. The institutional review board waiver was approved and granted 05/2010. Results: Central zone identified in 92%-93% of patients on T2-weighted images and 78%-88% on ADC maps without significant difference between identification rates (P=.63 and P=.15 and inter-reader agreement (κ) is 0.64 and 0.29, for T2-weighted images and ADC maps, respectively). All central zones were rated either curve type 1 or curve type 2 by both radiologists. No statistically significant difference between the two radiologists (P=.19) and inter-reader agreement was κ=0.37. Conclusions: Normal central zone demonstrates either type 1 (progressive) or type 2 (plateau) enhancement curves on dynamic contrast-enhanced MRI that can be potentially useful to differentiate central zone from prostate cancer that classically demonstrates a type 3 (wash-out) enhancement curve.

KW - Central zone

KW - Dynamic contrast-enhanced magnetic resonance imaging

KW - Prostate cancer

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