Abstract
Rationale and Objectives: Evaluate qualitative dynamic contrast-enhanced magnetic resonance imaging (MRI) characteristics of normal central zone based on recently described central zone MRI features. Materials and Methods: Institutional review board-approved, Health Insurance Portability and Accountability Act compliant study, 59 patients with prostate cancer, histopathology proven to not involve central zone or prostate base, underwent endorectal MRI before prostatectomy. Two readers independently reviewed T2-weighted images and apparent diffusion coefficient (ADC) maps identifying normal central zone based on low signal intensity and location. Next, two readers drew bilateral central zone regions of interest on dynamic contrast-enhanced magnetic resonance images in consensus and independently recorded enhancement curve types as type 1 (progressive), type 2 (plateau), and type 3 (wash-out). Identification rates of normal central zone and enhancement curve type were recorded and compared for each reviewer. The institutional review board waiver was approved and granted 05/2010. Results: Central zone identified in 92%-93% of patients on T2-weighted images and 78%-88% on ADC maps without significant difference between identification rates (P=.63 and P=.15 and inter-reader agreement (κ) is 0.64 and 0.29, for T2-weighted images and ADC maps, respectively). All central zones were rated either curve type 1 or curve type 2 by both radiologists. No statistically significant difference between the two radiologists (P=.19) and inter-reader agreement was κ=0.37. Conclusions: Normal central zone demonstrates either type 1 (progressive) or type 2 (plateau) enhancement curves on dynamic contrast-enhanced MRI that can be potentially useful to differentiate central zone from prostate cancer that classically demonstrates a type 3 (wash-out) enhancement curve.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 569-577 |
| Number of pages | 9 |
| Journal | Academic radiology |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Externally published | Yes |
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Keywords
- Central zone
- Dynamic contrast-enhanced magnetic resonance imaging
- Prostate cancer
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Dynamic contrast-enhanced MR imaging features of the normal central zone of the prostate. / Hansford, Barry; Karademir, Ibrahim; Peng, Yahui; Jiang, Yulei; Karczmar, Gregory; Thomas, Stephen; Yousuf, Ambereen; Antic, Tatjana; Eggener, Scott; Oto, Aytekin.
In: Academic radiology, Vol. 21, No. 5, 01.01.2014, p. 569-577.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dynamic contrast-enhanced MR imaging features of the normal central zone of the prostate
AU - Hansford, Barry
AU - Karademir, Ibrahim
AU - Peng, Yahui
AU - Jiang, Yulei
AU - Karczmar, Gregory
AU - Thomas, Stephen
AU - Yousuf, Ambereen
AU - Antic, Tatjana
AU - Eggener, Scott
AU - Oto, Aytekin
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Rationale and Objectives: Evaluate qualitative dynamic contrast-enhanced magnetic resonance imaging (MRI) characteristics of normal central zone based on recently described central zone MRI features. Materials and Methods: Institutional review board-approved, Health Insurance Portability and Accountability Act compliant study, 59 patients with prostate cancer, histopathology proven to not involve central zone or prostate base, underwent endorectal MRI before prostatectomy. Two readers independently reviewed T2-weighted images and apparent diffusion coefficient (ADC) maps identifying normal central zone based on low signal intensity and location. Next, two readers drew bilateral central zone regions of interest on dynamic contrast-enhanced magnetic resonance images in consensus and independently recorded enhancement curve types as type 1 (progressive), type 2 (plateau), and type 3 (wash-out). Identification rates of normal central zone and enhancement curve type were recorded and compared for each reviewer. The institutional review board waiver was approved and granted 05/2010. Results: Central zone identified in 92%-93% of patients on T2-weighted images and 78%-88% on ADC maps without significant difference between identification rates (P=.63 and P=.15 and inter-reader agreement (κ) is 0.64 and 0.29, for T2-weighted images and ADC maps, respectively). All central zones were rated either curve type 1 or curve type 2 by both radiologists. No statistically significant difference between the two radiologists (P=.19) and inter-reader agreement was κ=0.37. Conclusions: Normal central zone demonstrates either type 1 (progressive) or type 2 (plateau) enhancement curves on dynamic contrast-enhanced MRI that can be potentially useful to differentiate central zone from prostate cancer that classically demonstrates a type 3 (wash-out) enhancement curve.
AB - Rationale and Objectives: Evaluate qualitative dynamic contrast-enhanced magnetic resonance imaging (MRI) characteristics of normal central zone based on recently described central zone MRI features. Materials and Methods: Institutional review board-approved, Health Insurance Portability and Accountability Act compliant study, 59 patients with prostate cancer, histopathology proven to not involve central zone or prostate base, underwent endorectal MRI before prostatectomy. Two readers independently reviewed T2-weighted images and apparent diffusion coefficient (ADC) maps identifying normal central zone based on low signal intensity and location. Next, two readers drew bilateral central zone regions of interest on dynamic contrast-enhanced magnetic resonance images in consensus and independently recorded enhancement curve types as type 1 (progressive), type 2 (plateau), and type 3 (wash-out). Identification rates of normal central zone and enhancement curve type were recorded and compared for each reviewer. The institutional review board waiver was approved and granted 05/2010. Results: Central zone identified in 92%-93% of patients on T2-weighted images and 78%-88% on ADC maps without significant difference between identification rates (P=.63 and P=.15 and inter-reader agreement (κ) is 0.64 and 0.29, for T2-weighted images and ADC maps, respectively). All central zones were rated either curve type 1 or curve type 2 by both radiologists. No statistically significant difference between the two radiologists (P=.19) and inter-reader agreement was κ=0.37. Conclusions: Normal central zone demonstrates either type 1 (progressive) or type 2 (plateau) enhancement curves on dynamic contrast-enhanced MRI that can be potentially useful to differentiate central zone from prostate cancer that classically demonstrates a type 3 (wash-out) enhancement curve.
KW - Central zone
KW - Dynamic contrast-enhanced magnetic resonance imaging
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84897555175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897555175&partnerID=8YFLogxK
U2 - 10.1016/j.acra.2014.01.013
DO - 10.1016/j.acra.2014.01.013
M3 - Article
C2 - 24703469
AN - SCOPUS:84897555175
VL - 21
SP - 569
EP - 577
JO - Academic Radiology
JF - Academic Radiology
SN - 1076-6332
IS - 5
ER -