Dynamic conformal arc cranial stereotactic radiosurgery: Implications of multileaf collimator margin on dose-volume metrics

James Tanyi, E. J. Doss, C. M. Kato, D. L. Monaco, L. Z. Meng, Yiyi Chen, C. D. Kubicky, C. M. Marquez, M. Fuss

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: The effect of multileaf collimator (MLC) margin on target and normal tissue dose-volume metrics for intracranial stereotactic radiosurgery (SRS) was assessed. Methods: 118 intracranial lesions of 83 SRS patients formed the basis of this study. For each planning target volume (PTV), five separate treatment plans were generated with MLC margins of 21, 0, 1, 2 and 3mm, respectively. Identical treatment planning parameters were employed with a median of five dynamic conformal arcs using the Varian/BrainLab high-definition MLC for beam shaping. Prescription dose (PD) was such that 22Gy covered at least 95% of the PTV. Dose-volume and dose-response comparative metrics included conformity index, heterogeneity index, dose gradient, tumour control probability (TCP) and normal tissue complication probability (NTCP). Results: Target dose heterogeneity decreased with increasing MLC margin (p

Original languageEnglish (US)
JournalBritish Journal of Radiology
Volume85
Issue number1019
DOIs
StatePublished - Nov 2012

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Radiosurgery
Prescriptions
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Dynamic conformal arc cranial stereotactic radiosurgery : Implications of multileaf collimator margin on dose-volume metrics. / Tanyi, James; Doss, E. J.; Kato, C. M.; Monaco, D. L.; Meng, L. Z.; Chen, Yiyi; Kubicky, C. D.; Marquez, C. M.; Fuss, M.

In: British Journal of Radiology, Vol. 85, No. 1019, 11.2012.

Research output: Contribution to journalArticle

Tanyi, James ; Doss, E. J. ; Kato, C. M. ; Monaco, D. L. ; Meng, L. Z. ; Chen, Yiyi ; Kubicky, C. D. ; Marquez, C. M. ; Fuss, M. / Dynamic conformal arc cranial stereotactic radiosurgery : Implications of multileaf collimator margin on dose-volume metrics. In: British Journal of Radiology. 2012 ; Vol. 85, No. 1019.
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AU - Monaco, D. L.

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