Dupilumab with Topical Corticosteroids Provides Rapid and Sustained Improvement in Adults with Moderate-to-Severe Atopic Dermatitis Across Anatomic Regions Over 52 Weeks

Andrew Blauvelt, Marjolein de Bruin-Weller, Eric L. Simpson, Zhen Chen, Annie Zhang, Brad Shumel

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: In a 52-week, phase 3 clinical trial (LIBERTY AD CHRONOS) in adult patients with moderate-to-severe atopic dermatitis (AD), dupilumab in combination with topical corticosteroids (TCS) resulted in a significant improvement in overall Eczema Area and Severity Index (EASI) compared with placebo plus TCS. In a post hoc analysis, dupilumab significantly improved the overall extent and severity of AD across four anatomic regions (head and neck, trunk, upper extremities, lower extremities) over 16 weeks. However, as AD severity and presentation may vary by body region, this analysis sought to determine whether there are regional variations in dupilumab efficacy. Methods: Using data from the LIBERTY AD CHRONOS study, we performed a post hoc analysis of the mean percentage change in individual EASI signs (erythema, infiltration/papulation, excoriation, lichenification) from baseline through week 52 across four anatomic regions (head and neck, trunk, upper extremities, lower extremities). Results: Dupilumab plus TCS, compared with placebo plus TCS, significantly improved the severity of all individual AD signs to a similar extent across the four anatomic regions. Significant improvements in each sign were seen early, within the first 2–4 weeks of treatment, and were sustained through week 52 across all regions. Conclusions: In adult patients with moderate-to-severe AD, treatment with dupilumab resulted in rapid and sustained improvement in the signs of AD across all anatomic regions. Trial registration: LIBERTY AD CHRONOS (NCT02260986).

Original languageEnglish (US)
Pages (from-to)223-231
Number of pages9
JournalDermatology and Therapy
Volume12
Issue number1
DOIs
StatePublished - Jan 2022
Externally publishedYes

Keywords

  • Anatomic regions
  • Atopic dermatitis
  • Atopic eczema
  • Contact dermatitis
  • Cytokines
  • Dermatology
  • Dupilumab
  • EASI
  • Facial rash
  • Immunology
  • Signs

ASJC Scopus subject areas

  • Dermatology

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