Duodenal and gastric delivery of levodopa in parkinsonism

R. Kurlan, John Nutt, William Woodward, K. Rothfield, D. Lichter, C. Miller, Julie Carter, I. Shoulson

Research output: Contribution to journalArticle

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Abstract

To clarify the influence of gastric emptying on levodopa-related motor fluctuations in Parkinson's disease, we assessed mobility and plasma levodopa concentrations in 10 patients during five modes of levodopa administration: (1) standard intermittent oral (SIO), (2) intermittent duodenal (ID), (3) continuous duodenal infusion (CDI), (4) continuous gastric infusion (CGI), and (5) controlled-release Sinemet (CR-4). The rank order from greatest to least for both percentage of time 'on' and average mobility score was CDI, CGI, ID, CR-4, and SIO. The rank order for variance of means, a measure of fluctuation, from least to greatest for mobility was CDI, CGI, CR-4, ID, SIO, and for plasma levodopa concentrations was CDI, CGI, ID, SIO, and CR-4. The results demonstrate that it is possible to produce very steady plasma concentrations of levodopa with a corresponding reduction in motor fluctuations by continuous intraduodenal administration of the drug. This mode of delivery is an ideal model for the development of optimal continuous-release preparations of levodopa. Other enteral routes have produced a more variable plasma levodopa concentration and clinical response.

Original languageEnglish (US)
Pages (from-to)589-595
Number of pages7
JournalAnnals of Neurology
Volume23
Issue number6
StatePublished - 1988

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Parkinsonian Disorders
Levodopa
Stomach
Gastric Emptying
Small Intestine
Parkinson Disease
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kurlan, R., Nutt, J., Woodward, W., Rothfield, K., Lichter, D., Miller, C., ... Shoulson, I. (1988). Duodenal and gastric delivery of levodopa in parkinsonism. Annals of Neurology, 23(6), 589-595.

Duodenal and gastric delivery of levodopa in parkinsonism. / Kurlan, R.; Nutt, John; Woodward, William; Rothfield, K.; Lichter, D.; Miller, C.; Carter, Julie; Shoulson, I.

In: Annals of Neurology, Vol. 23, No. 6, 1988, p. 589-595.

Research output: Contribution to journalArticle

Kurlan, R, Nutt, J, Woodward, W, Rothfield, K, Lichter, D, Miller, C, Carter, J & Shoulson, I 1988, 'Duodenal and gastric delivery of levodopa in parkinsonism', Annals of Neurology, vol. 23, no. 6, pp. 589-595.
Kurlan R, Nutt J, Woodward W, Rothfield K, Lichter D, Miller C et al. Duodenal and gastric delivery of levodopa in parkinsonism. Annals of Neurology. 1988;23(6):589-595.
Kurlan, R. ; Nutt, John ; Woodward, William ; Rothfield, K. ; Lichter, D. ; Miller, C. ; Carter, Julie ; Shoulson, I. / Duodenal and gastric delivery of levodopa in parkinsonism. In: Annals of Neurology. 1988 ; Vol. 23, No. 6. pp. 589-595.
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