Dual-targeted molecular imaging of cancer

Emily B. Ehlerding, Lingyi Sun, Xiaoli Lan, Dexing Zeng, Weibo Cai

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Molecular imaging is critical to personalized and precision medicine. Although singly targeted imaging probes are making an impact both clinically and preclinically, molecular imaging strategies using bispecific probes have enabled improved visualization of cancer in recent years through synergistic targeting of two ligands. In this Focus on Molecular Imaging review, we outline how peptide-, antibody-, and nanoparticle-based platforms have affected this emerging strategy, providing examples and pointing out areas in which the greatest clinical impact may be realized.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalJournal of Nuclear Medicine
Volume59
Issue number3
DOIs
StatePublished - Mar 1 2018

Keywords

  • Bispecific antibody fragment
  • Cancer
  • Dual-targeted
  • Molecular imaging
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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