Dual-energy X-ray absorptiometry for quantification of visceral fat

Sanjiv Kaul, Megan P. Rothney, Dawn Peters, Wynn K. Wacker, Cynthia E. Davis, Michael Shapiro, David L. Ergun

Research output: Contribution to journalArticle

264 Citations (Scopus)

Abstract

Obesity is the major risk factor for metabolic syndrome and through it diabetes as well as cardiovascular disease. Visceral fat (VF) rather than subcutaneous fat (SF) is the major predictor of adverse events. Currently, the reference standard for measuring VF is abdominal X-ray computed tomography (CT) or magnetic resonance imaging (MRI), requiring highly used clinical equipment. Dual-energy X-ray absorptiometry (DXA) can accurately measure body composition with high-precision, low X-ray exposure, and short-scanning time. The purpose of this study was to validate a new fully automated method whereby abdominal VF can be measured by DXA. Furthermore, we explored the association between DXA-derived abdominal VF and several other indices for obesity: BMI, waist circumference, waist-to-hip ratio, and DXA-derived total abdominal fat (AF), and SF. We studied 124 adult men and women, aged 18-90 years, representing a wide range of BMI values (18.5-40 kg/m 2) measured with both DXA and CT in a fasting state within a one hour interval. The coefficient of determination (r 2) for regression of CT on DXA values was 0.959 for females, 0.949 for males, and 0.957 combined. The 95% confidence interval for r was 0.968 to 0.985 for the combined data. The 95% confidence interval for the mean of the differences between CT and DXA VF volume was 96.0 to 16.3 cm 3. Bland-Altman bias was 67 cm 3 for females and 43 cm 3 for males. The 95% limits of agreement were 339 to 472 cm 3 for females and 379 to 465 cm 3 for males. Combined, the bias was 56 cm 3 with 95% limits of agreement of 355 to 468 cm 3. The correlations between DXA-derived VF and BMI, waist circumference, waist-to-hip ratio, and DXA-derived AF and SF ranged from poor to modest. We conclude that DXA can measure abdominal VF precisely in both men and women. This simple noninvasive method with virtually no radiation can therefore be used to measure VF in individual patients and help define diabetes and cardiovascular risk.

Original languageEnglish (US)
Pages (from-to)1313-1318
Number of pages6
JournalObesity
Volume20
Issue number6
DOIs
StatePublished - Jun 2012

Fingerprint

Intra-Abdominal Fat
Photon Absorptiometry
Subcutaneous Fat
Abdominal Fat
X Ray Computed Tomography
Waist-Hip Ratio
Waist Circumference
Obesity
Tomography
Confidence Intervals
Body Composition
Fasting
Cardiovascular Diseases
Magnetic Resonance Imaging
X-Rays
Radiation
Equipment and Supplies

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Dual-energy X-ray absorptiometry for quantification of visceral fat. / Kaul, Sanjiv; Rothney, Megan P.; Peters, Dawn; Wacker, Wynn K.; Davis, Cynthia E.; Shapiro, Michael; Ergun, David L.

In: Obesity, Vol. 20, No. 6, 06.2012, p. 1313-1318.

Research output: Contribution to journalArticle

Kaul, Sanjiv ; Rothney, Megan P. ; Peters, Dawn ; Wacker, Wynn K. ; Davis, Cynthia E. ; Shapiro, Michael ; Ergun, David L. / Dual-energy X-ray absorptiometry for quantification of visceral fat. In: Obesity. 2012 ; Vol. 20, No. 6. pp. 1313-1318.
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