D2 dopamine receptor gene not linked to manic- depression in three families

W. Byerley, M. Leppert, P. O’Connell, C. Mellon, J. Holik, A. Lubbers, F. Reimherr, S. Jenson, K. Hill, P. Wender, David Grandy, M. Litt, J. M. Lalouel, O. Civelli, R. White

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    We ascertained four multigenerational pedigrees segregating manic-depression in which transmission of illness was compatible with autosomal dominant inheritance. As alterations in dopaminergic neurotransmission have been implicated in the pathogenesis of this disease and as there is a report of a family in which manic-depression may be associated with chromosomal break at 11q23-34, we undertook a linkage analysis between manic-depression in four families and the D2 dopamine receptor gene that maps to chromosome 11q22-23. In three of four kindreds, that were informative for analysis, no evidence of linkage was found (lod score - 7.99 at θ = 0.00).

    Original languageEnglish (US)
    Pages (from-to)55-62
    Number of pages8
    JournalPsychiatric Genetics
    Volume1
    Issue number2
    StatePublished - 1990

    Fingerprint

    Lod Score
    Chromosome Breakage
    Dopamine D2 Receptors
    Pedigree
    Synaptic Transmission
    Chromosomes
    Genes

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)
    • Psychiatry and Mental health
    • Biological Psychiatry

    Cite this

    Byerley, W., Leppert, M., O’Connell, P., Mellon, C., Holik, J., Lubbers, A., ... White, R. (1990). D2 dopamine receptor gene not linked to manic- depression in three families. Psychiatric Genetics, 1(2), 55-62.

    D2 dopamine receptor gene not linked to manic- depression in three families. / Byerley, W.; Leppert, M.; O’Connell, P.; Mellon, C.; Holik, J.; Lubbers, A.; Reimherr, F.; Jenson, S.; Hill, K.; Wender, P.; Grandy, David; Litt, M.; Lalouel, J. M.; Civelli, O.; White, R.

    In: Psychiatric Genetics, Vol. 1, No. 2, 1990, p. 55-62.

    Research output: Contribution to journalArticle

    Byerley, W, Leppert, M, O’Connell, P, Mellon, C, Holik, J, Lubbers, A, Reimherr, F, Jenson, S, Hill, K, Wender, P, Grandy, D, Litt, M, Lalouel, JM, Civelli, O & White, R 1990, 'D2 dopamine receptor gene not linked to manic- depression in three families', Psychiatric Genetics, vol. 1, no. 2, pp. 55-62.
    Byerley W, Leppert M, O’Connell P, Mellon C, Holik J, Lubbers A et al. D2 dopamine receptor gene not linked to manic- depression in three families. Psychiatric Genetics. 1990;1(2):55-62.
    Byerley, W. ; Leppert, M. ; O’Connell, P. ; Mellon, C. ; Holik, J. ; Lubbers, A. ; Reimherr, F. ; Jenson, S. ; Hill, K. ; Wender, P. ; Grandy, David ; Litt, M. ; Lalouel, J. M. ; Civelli, O. ; White, R. / D2 dopamine receptor gene not linked to manic- depression in three families. In: Psychiatric Genetics. 1990 ; Vol. 1, No. 2. pp. 55-62.
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    abstract = "We ascertained four multigenerational pedigrees segregating manic-depression in which transmission of illness was compatible with autosomal dominant inheritance. As alterations in dopaminergic neurotransmission have been implicated in the pathogenesis of this disease and as there is a report of a family in which manic-depression may be associated with chromosomal break at 11q23-34, we undertook a linkage analysis between manic-depression in four families and the D2 dopamine receptor gene that maps to chromosome 11q22-23. In three of four kindreds, that were informative for analysis, no evidence of linkage was found (lod score - 7.99 at θ = 0.00).",
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    AU - Byerley, W.

    AU - Leppert, M.

    AU - O’Connell, P.

    AU - Mellon, C.

    AU - Holik, J.

    AU - Lubbers, A.

    AU - Reimherr, F.

    AU - Jenson, S.

    AU - Hill, K.

    AU - Wender, P.

    AU - Grandy, David

    AU - Litt, M.

    AU - Lalouel, J. M.

    AU - Civelli, O.

    AU - White, R.

    PY - 1990

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