D2 dopamine receptor gene not linked to manic- depression in three families

W. Byerley; M. Leppert; P. O’Connell; C. Mellon; J. Holik; A. Lubbers; F. Reimherr; S. Jenson; K. Hill; P. Wender; D. Grandy; M. Litt; J. M. Lalouel; O. Civelli; R. White

doi:10.1097/00041444-199001020-00006

D₂ dopamine receptor gene not linked to manic- depression in three families

W. Byerley, M. Leppert, P. O’Connell, C. Mellon, J. Holik, A. Lubbers, F. Reimherr, S. Jenson, K. Hill, P. Wender, D. Grandy, M. Litt, J. M. Lalouel, O. Civelli, R. White

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Abstract

We ascertained four multigenerational pedigrees segregating manic-depression in which transmission of illness was compatible with autosomal dominant inheritance. As alterations in dopaminergic neurotransmission have been implicated in the pathogenesis of this disease and as there is a report of a family in which manic-depression may be associated with chromosomal break at 11q23-34, we undertook a linkage analysis between manic-depression in four families and the D₂ dopamine receptor gene that maps to chromosome 11q22-23. In three of four kindreds, that were informative for analysis, no evidence of linkage was found (lod score - 7.99 at θ = 0.00).

Original language	English (US)
Pages (from-to)	55-62
Number of pages	8
Journal	Psychiatric Genetics
Volume	1
Issue number	2
DOIs	https://doi.org/10.1097/00041444-199001020-00006
State	Published - Jan 1990

ASJC Scopus subject areas

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

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title = "D2 dopamine receptor gene not linked to manic- depression in three families",

abstract = "We ascertained four multigenerational pedigrees segregating manic-depression in which transmission of illness was compatible with autosomal dominant inheritance. As alterations in dopaminergic neurotransmission have been implicated in the pathogenesis of this disease and as there is a report of a family in which manic-depression may be associated with chromosomal break at 11q23-34, we undertook a linkage analysis between manic-depression in four families and the D2 dopamine receptor gene that maps to chromosome 11q22-23. In three of four kindreds, that were informative for analysis, no evidence of linkage was found (lod score - 7.99 at θ = 0.00).",

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T1 - D2 dopamine receptor gene not linked to manic- depression in three families

AU - Byerley, W.

AU - Leppert, M.

AU - O’Connell, P.

AU - Mellon, C.

AU - Holik, J.

AU - Lubbers, A.

AU - Reimherr, F.

AU - Jenson, S.

AU - Hill, K.

AU - Wender, P.

AU - Grandy, D.

AU - Litt, M.

AU - Lalouel, J. M.

AU - Civelli, O.

AU - White, R.

PY - 1990/1

Y1 - 1990/1

N2 - We ascertained four multigenerational pedigrees segregating manic-depression in which transmission of illness was compatible with autosomal dominant inheritance. As alterations in dopaminergic neurotransmission have been implicated in the pathogenesis of this disease and as there is a report of a family in which manic-depression may be associated with chromosomal break at 11q23-34, we undertook a linkage analysis between manic-depression in four families and the D2 dopamine receptor gene that maps to chromosome 11q22-23. In three of four kindreds, that were informative for analysis, no evidence of linkage was found (lod score - 7.99 at θ = 0.00).

AB - We ascertained four multigenerational pedigrees segregating manic-depression in which transmission of illness was compatible with autosomal dominant inheritance. As alterations in dopaminergic neurotransmission have been implicated in the pathogenesis of this disease and as there is a report of a family in which manic-depression may be associated with chromosomal break at 11q23-34, we undertook a linkage analysis between manic-depression in four families and the D2 dopamine receptor gene that maps to chromosome 11q22-23. In three of four kindreds, that were informative for analysis, no evidence of linkage was found (lod score - 7.99 at θ = 0.00).

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D₂ dopamine receptor gene not linked to manic- depression in three families

Abstract

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