Drugs and Transporters in Kinetoplastid Protozoa

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Kinetoplastid protozoa express hundreds of membrane transport proteins that allow them to take up nutrients, establish ion gradients, efflux metabolites, translocate compounds from one intracellular compartment to another, and take up or export drugs. The combination of molecular cloning, genetic approaches, and the completed genome projects for Trypanosoma brucei, Leishmania major, and Trypanosoma cruzi have allowed detailed functional analysis of various transporters and predictions about the likely functions of others. Thus many opportunities exist to define the biological and pharmacological properties of parasite transporters whose genes were often difficult to identify in the pregenomic era. A subset of these transporters that are essential for parasite viability could serve as targets for novel drug therapies by identifying compounds that interfere with their uptake functions. Other permeases provide routes for uptake of selectively cytotoxic compounds and can thus be useful for delivery of drugs. Drug resistance may develop in strains where such drug uptake transporters are nonfunctional or in parasites that over-express other permeases that export a drug. A summary of recent work on Leishmania transporters for glucose and for purines is provided as an example of permeases that are being studied in molecular detail.

Original languageEnglish (US)
Pages (from-to)22-32
Number of pages11
JournalAdvances in Experimental Medicine and Biology
Volume625
DOIs
StatePublished - 2008

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Protozoa
Membrane Transport Proteins
Parasites
Pharmaceutical Preparations
Leishmania major
Purines
Trypanosoma brucei brucei
Genes
Trypanosoma cruzi
Molecular Cloning
Drug therapy
Functional analysis
Drug Resistance
Cloning
Molecular Biology
Metabolites
Nutrients
Genome
Pharmacology
Ions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Drugs and Transporters in Kinetoplastid Protozoa. / Landfear, Scott.

In: Advances in Experimental Medicine and Biology, Vol. 625, 2008, p. 22-32.

Research output: Contribution to journalArticle

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