Drugs and Pituitary Function

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Many drugs, both prescription and illicit, can affect pituitary function. Drug withdrawal sometimes reverses these effects, but pituitary hypo- or hyperfunction may persist for the long term. Several therapies used in an acute setting can also impact the hypothalamic-pituitary axis. The list of potential "culprit" drugs is large and expanding; drugs such as opiates, anti-CTLA-4 antibody therapy, and tyrosine kinase inhibitor (TKI) inhibitors have been recently found to have profound effects on the pituitary axes. Many therapies, including antidepressants, antipsychotics, antihistamines, and proton-pump inhibitors can raise prolactin levels and a complete drug history is essential in the differential diagnosis of hyperprolactinemia, especially when it coincides with the presence of a small pituitary adenoma. Increased awareness of drug effects on the pituitary should prompt early screening, or, in the presence of suggestive symptoms and/or abnormal laboratory values, expeditious treatment for hypopituitarism. Familiarity with the spectrum of pituitary dysfunction attributed to acute and chronic drug therapies is paramount to endocrinologists, oncologists, pain specialists, psychiatrists, intensivists, and internal medicine specialists.

Original languageEnglish (US)
Title of host publicationThe Pituitary
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Pages383-396
Number of pages14
ISBN (Print)9780128041697
DOIs
StatePublished - Jan 18 2017

Fingerprint

Pharmaceutical Preparations
Opiate Alkaloids
Drug Prescriptions
Hypopituitarism
Hyperprolactinemia
Proton Pump Inhibitors
Histamine Antagonists
Pituitary Neoplasms
Therapeutics
Internal Medicine
Prolactin
Protein-Tyrosine Kinases
Antidepressive Agents
Antipsychotic Agents
Psychiatry
Differential Diagnosis
History
Drug Therapy
Pain
Antibodies

Keywords

  • Alcohol
  • Altered pituitary hormone secretion
  • Amphetamines
  • Antidepressants
  • Antipsychotics
  • Dopamine
  • Glucocorticoids
  • Opiates
  • Substance abuse

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fleseriu, M. (2017). Drugs and Pituitary Function. In The Pituitary: Fourth Edition (pp. 383-396). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804169-7.00012-X

Drugs and Pituitary Function. / Fleseriu, Maria.

The Pituitary: Fourth Edition. Elsevier Inc., 2017. p. 383-396.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fleseriu, M 2017, Drugs and Pituitary Function. in The Pituitary: Fourth Edition. Elsevier Inc., pp. 383-396. https://doi.org/10.1016/B978-0-12-804169-7.00012-X
Fleseriu M. Drugs and Pituitary Function. In The Pituitary: Fourth Edition. Elsevier Inc. 2017. p. 383-396 https://doi.org/10.1016/B978-0-12-804169-7.00012-X
Fleseriu, Maria. / Drugs and Pituitary Function. The Pituitary: Fourth Edition. Elsevier Inc., 2017. pp. 383-396
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