Drug reward and intake in lines of mice selectively bred for divergent exploration of a hole board apparatus

C. L. Kliethermes, H. M. Kamens, John Jr Crabbe

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Individuals characterized as high-novelty seekers are more likely to abuse drugs than are low-novelty seekers, and it is possible that the biological substrates underlying novelty seeking and drug abuse are similar. We selectively bred replicate lines of mice from a B6D2 F3 hybrid stock for high exploratory behavior (HEB) or low exploratory behavior (LEB) as measured by the number of head dips on a hole board. To determine whether common genes might influence exploratory behavior and behaviors relevant to drug abuse, we tested HEB and LEB mice for conditioned place preference produced by ethanol and d-amphetamine and also examined oral methamphetamine intake. After four generations of selection, HEB and LEB mice did not differ in the magnitude of place preference for ethanol, but LEB mice showed a greater place preference for an amphetamine-paired location than did HEB mice. However, this difference did not replicate in mice tested from the fifth generation of selection. The selected lines also did not differ in sensitization to the locomotor stimulant effects of d-amphetamine that developed across the conditioning trials. Finally, HEB and LEB mice consumed equivalently low amounts of methamphetamine. These results suggest that common genes do not influence head dipping and several behaviors potentially relevant to drug abuse.

Original languageEnglish (US)
Pages (from-to)608-618
Number of pages11
JournalGenes, Brain and Behavior
Volume6
Issue number7
DOIs
StatePublished - Oct 2007

Fingerprint

Exploratory Behavior
Reward
Pharmaceutical Preparations
Substance-Related Disorders
Dextroamphetamine
Methamphetamine
Ethanol
Head
Amphetamine
Genes

Keywords

  • Alcohol
  • Amphetamine
  • Drug reward
  • Exploratory behavior
  • Genetics
  • Intake
  • Selective breeding

ASJC Scopus subject areas

  • Neuroscience(all)
  • Genetics

Cite this

Drug reward and intake in lines of mice selectively bred for divergent exploration of a hole board apparatus. / Kliethermes, C. L.; Kamens, H. M.; Crabbe, John Jr.

In: Genes, Brain and Behavior, Vol. 6, No. 7, 10.2007, p. 608-618.

Research output: Contribution to journalArticle

@article{738eed9ad1ec48788711e1bc67aaf767,
title = "Drug reward and intake in lines of mice selectively bred for divergent exploration of a hole board apparatus",
abstract = "Individuals characterized as high-novelty seekers are more likely to abuse drugs than are low-novelty seekers, and it is possible that the biological substrates underlying novelty seeking and drug abuse are similar. We selectively bred replicate lines of mice from a B6D2 F3 hybrid stock for high exploratory behavior (HEB) or low exploratory behavior (LEB) as measured by the number of head dips on a hole board. To determine whether common genes might influence exploratory behavior and behaviors relevant to drug abuse, we tested HEB and LEB mice for conditioned place preference produced by ethanol and d-amphetamine and also examined oral methamphetamine intake. After four generations of selection, HEB and LEB mice did not differ in the magnitude of place preference for ethanol, but LEB mice showed a greater place preference for an amphetamine-paired location than did HEB mice. However, this difference did not replicate in mice tested from the fifth generation of selection. The selected lines also did not differ in sensitization to the locomotor stimulant effects of d-amphetamine that developed across the conditioning trials. Finally, HEB and LEB mice consumed equivalently low amounts of methamphetamine. These results suggest that common genes do not influence head dipping and several behaviors potentially relevant to drug abuse.",
keywords = "Alcohol, Amphetamine, Drug reward, Exploratory behavior, Genetics, Intake, Selective breeding",
author = "Kliethermes, {C. L.} and Kamens, {H. M.} and Crabbe, {John Jr}",
year = "2007",
month = "10",
doi = "10.1111/j.1601-183X.2006.00289.x",
language = "English (US)",
volume = "6",
pages = "608--618",
journal = "Genes, Brain and Behavior",
issn = "1601-1848",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Drug reward and intake in lines of mice selectively bred for divergent exploration of a hole board apparatus

AU - Kliethermes, C. L.

AU - Kamens, H. M.

AU - Crabbe, John Jr

PY - 2007/10

Y1 - 2007/10

N2 - Individuals characterized as high-novelty seekers are more likely to abuse drugs than are low-novelty seekers, and it is possible that the biological substrates underlying novelty seeking and drug abuse are similar. We selectively bred replicate lines of mice from a B6D2 F3 hybrid stock for high exploratory behavior (HEB) or low exploratory behavior (LEB) as measured by the number of head dips on a hole board. To determine whether common genes might influence exploratory behavior and behaviors relevant to drug abuse, we tested HEB and LEB mice for conditioned place preference produced by ethanol and d-amphetamine and also examined oral methamphetamine intake. After four generations of selection, HEB and LEB mice did not differ in the magnitude of place preference for ethanol, but LEB mice showed a greater place preference for an amphetamine-paired location than did HEB mice. However, this difference did not replicate in mice tested from the fifth generation of selection. The selected lines also did not differ in sensitization to the locomotor stimulant effects of d-amphetamine that developed across the conditioning trials. Finally, HEB and LEB mice consumed equivalently low amounts of methamphetamine. These results suggest that common genes do not influence head dipping and several behaviors potentially relevant to drug abuse.

AB - Individuals characterized as high-novelty seekers are more likely to abuse drugs than are low-novelty seekers, and it is possible that the biological substrates underlying novelty seeking and drug abuse are similar. We selectively bred replicate lines of mice from a B6D2 F3 hybrid stock for high exploratory behavior (HEB) or low exploratory behavior (LEB) as measured by the number of head dips on a hole board. To determine whether common genes might influence exploratory behavior and behaviors relevant to drug abuse, we tested HEB and LEB mice for conditioned place preference produced by ethanol and d-amphetamine and also examined oral methamphetamine intake. After four generations of selection, HEB and LEB mice did not differ in the magnitude of place preference for ethanol, but LEB mice showed a greater place preference for an amphetamine-paired location than did HEB mice. However, this difference did not replicate in mice tested from the fifth generation of selection. The selected lines also did not differ in sensitization to the locomotor stimulant effects of d-amphetamine that developed across the conditioning trials. Finally, HEB and LEB mice consumed equivalently low amounts of methamphetamine. These results suggest that common genes do not influence head dipping and several behaviors potentially relevant to drug abuse.

KW - Alcohol

KW - Amphetamine

KW - Drug reward

KW - Exploratory behavior

KW - Genetics

KW - Intake

KW - Selective breeding

UR - http://www.scopus.com/inward/record.url?scp=34748918973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34748918973&partnerID=8YFLogxK

U2 - 10.1111/j.1601-183X.2006.00289.x

DO - 10.1111/j.1601-183X.2006.00289.x

M3 - Article

C2 - 17147699

AN - SCOPUS:34748918973

VL - 6

SP - 608

EP - 618

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

SN - 1601-1848

IS - 7

ER -