Drug-induced liver injury: Pattern recognition and future directions

Tanvir Haque, Eizaburo Sasatomi, Paul H. Hayashi

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Drug-induced liver injury (Dili) remains a significant clinical challenge and is the leading cause of acute liver failure in most countries. An aging population that uses more medications, a constant influx of newly developed drugs and a growing risk from unfamiliar herbal and dietary supplements will make Dili an increasing part of clinical practice. Currently, the most effective strategy for disease management is rapid identification, withholding the inciting agents, supportive care and having a firm understanding of the expected natural history. There are resources available to aid the clinician, including a new online "textbook" as well as causality assessment tools, but a heightened awareness of risk and the disease's varying phenotypes and good history-taking remain cornerstones to diagnosis. Looking ahead, growing registries of cases, pharmacoepidemiology studies and translational research into the mechanisms of injury may produce better diagnostic tools, markers for risk and disease, and prevention and therapeutics.

Original languageEnglish (US)
Pages (from-to)27-36
Number of pages10
JournalGut and Liver
Volume10
Issue number1
DOIs
StatePublished - Jan 2016
Externally publishedYes

Keywords

  • Diagnosis
  • Drug induced liver injury
  • Epidemiology
  • Hepatotoxicity
  • Herbal and dietary supplements

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint

Dive into the research topics of 'Drug-induced liver injury: Pattern recognition and future directions'. Together they form a unique fingerprint.

Cite this