TY - JOUR
T1 - Drug-Induced Hypothermia and Conditioned Place Aversion
AU - Cunningham, Christopher L.
AU - Niehus, Jill S.
PY - 1993/6
Y1 - 1993/6
N2 - This study examined the relationship between ethanol's thermal and motivational effects in a place conditioning task. In three experiments, male albino rats were exposed to a differential conditioning procedure that paired a distinctive tactile stimulus with ethanol (1.2 or 1.8 g/kg) or lithium chloride (3 meq/kg); a different stimulus was paired with saline. Different groups were exposed to ambient temperatures (Ta) of 5°, 21° or 32 °C during each 60-min conditioning trial. Both ethanol and lithium chloride produced hypothermia and conditioned place aversion in rats conditioned at normal Ta. Exposure to high Ta reduced drug-induced hypothermia, increased activity, and decreased conditioned place aversion. Exposure to low Ta did not enhance drug-induced hypothermia or change conditioned place aversion. In general, these findings support the suggestion that the hedonic effects of ethanol and lithium chloride interact with their thermal effects.
AB - This study examined the relationship between ethanol's thermal and motivational effects in a place conditioning task. In three experiments, male albino rats were exposed to a differential conditioning procedure that paired a distinctive tactile stimulus with ethanol (1.2 or 1.8 g/kg) or lithium chloride (3 meq/kg); a different stimulus was paired with saline. Different groups were exposed to ambient temperatures (Ta) of 5°, 21° or 32 °C during each 60-min conditioning trial. Both ethanol and lithium chloride produced hypothermia and conditioned place aversion in rats conditioned at normal Ta. Exposure to high Ta reduced drug-induced hypothermia, increased activity, and decreased conditioned place aversion. Exposure to low Ta did not enhance drug-induced hypothermia or change conditioned place aversion. In general, these findings support the suggestion that the hedonic effects of ethanol and lithium chloride interact with their thermal effects.
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U2 - 10.1037/0735-7044.107.3.468
DO - 10.1037/0735-7044.107.3.468
M3 - Article
C2 - 8329136
AN - SCOPUS:0027225351
SN - 0735-7044
VL - 107
SP - 468
EP - 479
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 3
ER -