Drug delivery with microsecond laser pulses into gelatin

Han Qun Shangguan, Lee W. Casperson, Alan Shearin, Kenton W. Gregory, Scott A. Prahl

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Photoacoustic drug delivery is a technique for localized drug delivery by laser-induced hydrodynamic pressure following cavitation bubble expansion and collapse. Photoacoustic drug delivery was investigated on gelatin-based thrombus models with planar and cylindrical geometries by use of one microsecond laser pulses. Solutions of a hydrophobic dye in mineral oil permitted monitoring of delivered colored oil into clear gelatin-based thrombus models. Cavitation bubble development and photoacoustic drug delivery were visualized with flash photography. This study demonstrated that cavitation is the governing mechanism for photoacoustic drug delivery, and the deepest penetration of colored oil in gels followed the bubble collapse. Spatial distribution measurements revealed that colored oil could be driven a few millimeters into the gels in both axial and radial directions, and the penetration was less than 500 µm when the gelatin structure was not fractured.

Original languageEnglish (US)
Title of host publicationTherapeutic Laser Applications, TLA 1998
PublisherOptica Publishing Group (formerly OSA)
Pages287-297
Number of pages11
ISBN (Electronic)9781557528209
StatePublished - 1998
EventTopical Meeting on Therapeutic Laser Applications, TLA 1998 - Orlando, United States
Duration: Mar 8 1998 → …

Publication series

NameOptics InfoBase Conference Papers

Conference

ConferenceTopical Meeting on Therapeutic Laser Applications, TLA 1998
Country/TerritoryUnited States
CityOrlando
Period3/8/98 → …

Keywords

  • Ablation
  • Cavitation bubble
  • Laser thrombolysis
  • Localized drug delivery
  • Photoacoustic transients

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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