Drug delivery with microsecond laser pulses into gelatin

Han Qun Shangguan, Lee W. Casperson, Alan Shearin, Kenton W. Gregory, Scott A. Prahl

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Photoacoustic drug delivery is a technique for localized drug delivery by laser-induced hydrodynamic pressure following cavitation bubble expansion and collapse. Photoacoustic drug delivery was investigated on gelatin-based thrombus models with planar and cylindrical geometries by use of one microsecond laser pulses. Solutions of a hydrophobic dye in mineral oil permitted monitoring of delivered colored oil into clear gelatin-based thrombus models. Cavitation bubble development and photoacoustic drug delivery were visualized with flash photography. This study demonstrated that cavitation is the governing mechanism for photoacoustic drug delivery, and the deepest penetration of colored oil in gels followed the bubble collapse. Spatial distribution measurements revealed that colored oil could be driven a few millimeters into the gels in both axial and radial directions, and the penetration was less than 500 μm when the gelatin structure was not fractured.

Original languageEnglish (US)
Pages (from-to)3347-3357
Number of pages11
JournalApplied Optics
Volume35
Issue number19
DOIs
StatePublished - Jul 1 1996

Keywords

  • Ablation
  • Cavitation bubble
  • Laser thrombolysis
  • Localized drug delivery
  • Photoacoustic transients

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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    Shangguan, H. Q., Casperson, L. W., Shearin, A., Gregory, K. W., & Prahl, S. A. (1996). Drug delivery with microsecond laser pulses into gelatin. Applied Optics, 35(19), 3347-3357. https://doi.org/10.1364/AO.35.003347