Dried plasma

State of the science and recent developments

Anthony E. Pusateri, Michael B. Given, Martin Schreiber, Philip C. Spinella, Shibani Pati, Rosemary A. Kozar, Abdul Khan, Joseph A. Dacorta, Kevin R. Kupferer, Nicolas Prat, Heather F. Pidcoke, Victor W. MacDonald, Wilbur W. Malloy, Anne Sailliol, Andrew P. Cap

    Research output: Contribution to journalReview article

    26 Citations (Scopus)

    Abstract

    The early transfusion of plasma is important to ensure optimal survival of patients with traumatic hemorrhage. In military and remote or austere civilian settings, it may be impossible to move patients to hospital facilities within the first few hours of injury. A dried plasma product with reduced logistical requirements is needed to enable plasma transfusion where medically needed, instead of only where freezers and other equipment are available. First developed in the 1930s, pooled lyophilized plasma was widely used by British and American forces in WWII and the Korean War. Historical dried plasma products solved the logistical problem but were abandoned because of disease transmission. Modern methods to improve blood safety have made it possible to produce safe and effective dried plasma. Dried plasma products are available in France, Germany, South Africa, and a limited number of other countries. However, no product is available in the US. Promising products are in development that employ different methods of drying, pathogen reduction, pooling, packaging, and other approaches. Although challenges exist, the in vitro and in vivo data suggest that these products have great potential to be safe and effective. The history, state of the science, and recent developments in dried plasma are reviewed.

    Original languageEnglish (US)
    Pages (from-to)S128-S139
    JournalTransfusion
    Volume56
    DOIs
    StatePublished - Apr 1 2016

    Fingerprint

    Blood Safety
    Product Packaging
    South Africa
    France
    Germany
    History
    Hemorrhage
    Equipment and Supplies
    Survival
    Wounds and Injuries
    In Vitro Techniques

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Medicine(all)
    • Hematology

    Cite this

    Pusateri, A. E., Given, M. B., Schreiber, M., Spinella, P. C., Pati, S., Kozar, R. A., ... Cap, A. P. (2016). Dried plasma: State of the science and recent developments. Transfusion, 56, S128-S139. https://doi.org/10.1111/trf.13580

    Dried plasma : State of the science and recent developments. / Pusateri, Anthony E.; Given, Michael B.; Schreiber, Martin; Spinella, Philip C.; Pati, Shibani; Kozar, Rosemary A.; Khan, Abdul; Dacorta, Joseph A.; Kupferer, Kevin R.; Prat, Nicolas; Pidcoke, Heather F.; MacDonald, Victor W.; Malloy, Wilbur W.; Sailliol, Anne; Cap, Andrew P.

    In: Transfusion, Vol. 56, 01.04.2016, p. S128-S139.

    Research output: Contribution to journalReview article

    Pusateri, AE, Given, MB, Schreiber, M, Spinella, PC, Pati, S, Kozar, RA, Khan, A, Dacorta, JA, Kupferer, KR, Prat, N, Pidcoke, HF, MacDonald, VW, Malloy, WW, Sailliol, A & Cap, AP 2016, 'Dried plasma: State of the science and recent developments', Transfusion, vol. 56, pp. S128-S139. https://doi.org/10.1111/trf.13580
    Pusateri AE, Given MB, Schreiber M, Spinella PC, Pati S, Kozar RA et al. Dried plasma: State of the science and recent developments. Transfusion. 2016 Apr 1;56:S128-S139. https://doi.org/10.1111/trf.13580
    Pusateri, Anthony E. ; Given, Michael B. ; Schreiber, Martin ; Spinella, Philip C. ; Pati, Shibani ; Kozar, Rosemary A. ; Khan, Abdul ; Dacorta, Joseph A. ; Kupferer, Kevin R. ; Prat, Nicolas ; Pidcoke, Heather F. ; MacDonald, Victor W. ; Malloy, Wilbur W. ; Sailliol, Anne ; Cap, Andrew P. / Dried plasma : State of the science and recent developments. In: Transfusion. 2016 ; Vol. 56. pp. S128-S139.
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