TY - JOUR
T1 - DPP4 inhibitors and cardiovascular outcomes
T2 - safety on heart failure
AU - Xia, Chang
AU - Goud, Aditya
AU - D’Souza, Jason
AU - Dahagam, Chanukya H.
AU - Rao, Xiaoquan
AU - Rajagopalan, Sanjay
AU - Zhong, Jixin
N1 - Funding Information:
This work was supported by grants from NIH (K01 DK105108), AHA (15SDG25700381 and 13POST17210033), NSFC (81670431), and Mid-Atlantic Nutrition Obesity Research Center (NORC Pilot & Feasibility Program) under NIH award number P30DK072488. X.R. was supported by K99ES026241 and T32DK098107.
Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Diabetes is an important risk factor for cardiovascular disease. However, clinical data suggests intensive glycemic control significantly increase rather than decrease cardiovascular mortality, which is largely due to the fact that a majority of oral anti-diabetic drugs have adverse cardiovascular effect. There are several large-scale clinical trials evaluating the cardiovascular safety of DPP4 inhibitors, a novel class of oral anti-diabetic medications, which have been recently completed. They were proven to be safe with regard to cardiovascular outcomes. However, concerns on the safety of heart failure have been raised as the SAVOR-TIMI 53 trial reported a 27% increase in the risk for heart failure hospitalization in diabetic patients treated with DPP4 inhibitor saxagliptin. In this review, we will discuss recent advances in the heart failure effects of DPP4 inhibition and GLP-1 agonism.
AB - Diabetes is an important risk factor for cardiovascular disease. However, clinical data suggests intensive glycemic control significantly increase rather than decrease cardiovascular mortality, which is largely due to the fact that a majority of oral anti-diabetic drugs have adverse cardiovascular effect. There are several large-scale clinical trials evaluating the cardiovascular safety of DPP4 inhibitors, a novel class of oral anti-diabetic medications, which have been recently completed. They were proven to be safe with regard to cardiovascular outcomes. However, concerns on the safety of heart failure have been raised as the SAVOR-TIMI 53 trial reported a 27% increase in the risk for heart failure hospitalization in diabetic patients treated with DPP4 inhibitor saxagliptin. In this review, we will discuss recent advances in the heart failure effects of DPP4 inhibition and GLP-1 agonism.
KW - Cardiovascular outcomes
KW - DPP4
KW - Heart failure
KW - Incretin
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U2 - 10.1007/s10741-017-9617-4
DO - 10.1007/s10741-017-9617-4
M3 - Review article
C2 - 28417296
AN - SCOPUS:85017517115
VL - 22
SP - 299
EP - 304
JO - Heart Failure Reviews
JF - Heart Failure Reviews
SN - 1382-4147
IS - 3
ER -