Down's syndrome affects results of surgical correction of complete atrioventricular canal

Cynthia Morris, David Magilke, Mark Reller

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

From 1981 through June 1989, 59 children had surgery for a complete atrioventricular (AV) canal defect at Oregon Health Sciences University. We compared the morbidity, mortality, and hemodynamic status of 47 children with and 12 without Down's syndrome through review of operative, clinical, and cardiac catheterization records. Overall, 10 children with Down's syndrome have died, nine from cardiac cause within 90 days of surgery. The 2-year survival of these children was 77±6% as compared to 100% in children without Down's syndrome (p=0.08). Early age at surgery, the surgical anatomy of the AV canal, and gender had no significant effect on survival. Before surgery, the hemodynamic status of Down's syndrome and non-Down's syndrome children did not differ; in a small group of post-operative catheterization, right heart pressures and pulmonary vascular resistance remained significantly higher in the Down's syndrome as compared to non-Down's syndrome children. These trends to higher mortality and poorer postoperative hemodynamics in children with Down's syndrome may necessitate closer follow-up if confirmed in other cohorts.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalPediatric Cardiology
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 1992

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Keywords

  • Atrioventricular canal
  • Cardiac surgery
  • Down's syndrome
  • Survival

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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