Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques

Levelle D. Harris, Brian Tabb, Donald L. Sodora, Mirko Paiardini, Nichole R. Klatt, Daniel C. Douek, Guido Silvestri, Michaela Müller-Trutwin, Ivona Vasile-Pandrea, Cristian Apetrei, Vanessa Hirsch, Jeffrey Lifson, Jason M. Brenchley, Jacob D. Estes

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

The mechanisms underlying the AIDS resistance of natural hosts for simian immunodeficiency virus (SIV) remain unknown. Recently, it was proposed that natural SIV hosts avoid disease because their plasmacytoid dendritic cells (pDCs) are intrinsically unable to produce alpha interferon (IFN-α) in response to SIV RNA stimulation. However, here we show that (i) acute SIV infections of natural hosts are associated with a rapid and robust type I IFN response in vivo, (ii) pDCs are the principal in vivo producers of IFN-α/β at peak acute infection in lymphatic tissues, and (iii) natural SIV hosts downregulate these responses in early chronic infection. In contrast, persistently high type I IFN responses are observed during pathogenic SIV infection of rhesus macaques.

Original languageEnglish (US)
Pages (from-to)7886-7891
Number of pages6
JournalJournal of virology
Volume84
Issue number15
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Harris, L. D., Tabb, B., Sodora, D. L., Paiardini, M., Klatt, N. R., Douek, D. C., Silvestri, G., Müller-Trutwin, M., Vasile-Pandrea, I., Apetrei, C., Hirsch, V., Lifson, J., Brenchley, J. M., & Estes, J. D. (2010). Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques. Journal of virology, 84(15), 7886-7891. https://doi.org/10.1128/JVI.02612-09