Double feature at the signalplex

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In this issue of Molecular Pharmacology, Oliveras-Reyes et al. (p. 356) describe the agonist-stimulated formation of a caveolin-dependent signalplex that includes both the angiotensin AT1 receptor and the epidermal growth factor receptor, and probably also a number of other signal transduction intermediates. The signalplex is thought to facilitate the action of protein kinases that mediate angiotensin II-induced transactivation of the epidermal growth factor receptor and activation of extracellular signal-regulated kinase, and epidermal growth factor-induced inositol phosphate accumulation and phosphorylation/desensitization of the AT1 receptor. This work contributes to an emerging view of the complexity and nonlinearity of signaling via G protein-coupled receptors and receptor tyrosine kinases, and of the importance of membrane compartmentalization to signal transduction.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalMolecular Pharmacology
Volume68
Issue number2
DOIs
StatePublished - Aug 2005

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Epidermal Growth Factor Receptor
Signal Transduction
Caveolins
Angiotensin Type 1 Receptor
Inositol Phosphates
Extracellular Signal-Regulated MAP Kinases
Receptor Protein-Tyrosine Kinases
G-Protein-Coupled Receptors
Epidermal Growth Factor
Angiotensin II
Protein Kinases
Transcriptional Activation
Phosphorylation
Pharmacology
Membranes

ASJC Scopus subject areas

  • Pharmacology

Cite this

Double feature at the signalplex. / Neve, Kim.

In: Molecular Pharmacology, Vol. 68, No. 2, 08.2005, p. 275-278.

Research output: Contribution to journalArticle

Neve, Kim. / Double feature at the signalplex. In: Molecular Pharmacology. 2005 ; Vol. 68, No. 2. pp. 275-278.
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