Double feature at the signalplex

Research output: Contribution to journalReview article

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Abstract

In this issue of Molecular Pharmacology, Oliveras-Reyes et al. (p. 356) describe the agonist-stimulated formation of a caveolin-dependent signalplex that includes both the angiotensin AT1 receptor and the epidermal growth factor receptor, and probably also a number of other signal transduction intermediates. The signalplex is thought to facilitate the action of protein kinases that mediate angiotensin II-induced transactivation of the epidermal growth factor receptor and activation of extracellular signal-regulated kinase, and epidermal growth factor-induced inositol phosphate accumulation and phosphorylation/desensitization of the AT1 receptor. This work contributes to an emerging view of the complexity and nonlinearity of signaling via G protein-coupled receptors and receptor tyrosine kinases, and of the importance of membrane compartmentalization to signal transduction.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalMolecular pharmacology
Volume68
Issue number2
DOIs
StatePublished - Aug 1 2005

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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