Double dissociation between long-term depression and dendritic spine morphology in cerebellar Purkinje cells

Andrei D. Sdrulla, David J. Linden

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Experiments in hippocampal area CA1 suggest that long-term potentiation could be associated with spine addition and enlargement, and long-term depression (LTD) with spine shrinkage and loss. Is this a general principle of synaptic plasticity? We used two-photon microscopy to measure dendritic spines in rat cerebellar Purkinje cells. Neither local synaptic induction of LTD nor global chemical induction of LTD changed spine number or size. Conversely, a manipulation that evoked persistent dendritic spine retraction did not alter parallel fiber-evoked excitatory postsynaptic currents.

Original languageEnglish (US)
Pages (from-to)546-548
Number of pages3
JournalNature Neuroscience
Volume10
Issue number5
DOIs
StatePublished - May 1 2007

ASJC Scopus subject areas

  • Neuroscience(all)

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