Double dissociation between long-term depression and dendritic spine morphology in cerebellar Purkinje cells

Andrei Sdrulla, David J. Linden

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Experiments in hippocampal area CA1 suggest that long-term potentiation could be associated with spine addition and enlargement, and long-term depression (LTD) with spine shrinkage and loss. Is this a general principle of synaptic plasticity? We used two-photon microscopy to measure dendritic spines in rat cerebellar Purkinje cells. Neither local synaptic induction of LTD nor global chemical induction of LTD changed spine number or size. Conversely, a manipulation that evoked persistent dendritic spine retraction did not alter parallel fiber-evoked excitatory postsynaptic currents.

Original languageEnglish (US)
Pages (from-to)546-548
Number of pages3
JournalNature Neuroscience
Volume10
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

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Dendritic Spines
Purkinje Cells
Spine
Long-Term Synaptic Depression
Neuronal Plasticity
Long-Term Potentiation
Excitatory Postsynaptic Potentials
Photons
Microscopy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Double dissociation between long-term depression and dendritic spine morphology in cerebellar Purkinje cells. / Sdrulla, Andrei; Linden, David J.

In: Nature Neuroscience, Vol. 10, No. 5, 05.2007, p. 546-548.

Research output: Contribution to journalArticle

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