Dose to the developing dentition during therapeutic irradiation

Organ at risk determination and clinical implications

Reid Thompson, Ralf A. Schneider, Francesca Albertini, Antony J. Lomax, Carmen Ares, Gudrun Goitein, Eugen B. Hug

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Irradiation of pediatric facial structures can cause severe impairment of permanent teeth later in life. We therefore focused on primary and permanent teeth as organs at risk, investigating the ability to identify individual teeth in children and infants and to correlate dose distributions with subsequent dental toxicity. Methods and Materials: We retrospectively reviewed 14 pediatric patients who received a maximum dose >20 Gy(relative biological effectiveness, RBE) to 1 or more primary or permanent teeth between 2003 and 2009. The patients (aged 1-16 years) received spot-scanning proton therapy with 46 to 66 Gy(RBE) in 23 to 33 daily fractions for a variety of tumors, including rhabdomyosarcoma (n=10), sarcoma (n=2), teratoma (n=1), and carcinoma (n=1). Individual teeth were contoured on axial slices from planning computed tomography (CT) scans. Dose-volume histogram data were retrospectively obtained from total calculated delivered treatments. Dental follow-up information was obtained from external care providers. Results: All primary teeth and permanent incisors, canines, premolars, and first and second molars were identifiable on CT scans in all patients as early as 1 year of age. Dose-volume histogram analysis showed wide dose variability, with a median 37 Gy(RBE) per tooth dose range across all individuals, and a median 50 Gy(RBE) intraindividual dose range across all teeth. Dental follow-up revealed absence of significant toxicity in 7 of 10 patients but severe localized toxicity in teeth receiving >20 Gy(RBE) among 3 patients who were all treated at <4 years of age. Conclusions: CT-based assessment of dose distribution to individual teeth is feasible, although delayed calcification may complicate tooth identification in the youngest patients. Patterns of dental dose exposure vary markedly within and among patients, corresponding to rapid dose falloff with protons. Severe localized dental toxicity was observed in a few patients receiving the largest doses of radiation at the youngest ages; however, multiple factors including concurrent chemotherapy confounded the dose-effect relationship. Further studies with larger cohorts and appropriate controls will be required.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume86
Issue number1
DOIs
StatePublished - May 1 2013
Externally publishedYes

Fingerprint

Organs at Risk
Dentition
organs
teeth
Tooth
dosage
irradiation
Relative Biological Effectiveness
toxicity
Therapeutics
tomography
Deciduous Tooth
histograms
Tomography
cancer
calcification
Proton Therapy
Pediatrics
protons
impairment

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Dose to the developing dentition during therapeutic irradiation : Organ at risk determination and clinical implications. / Thompson, Reid; Schneider, Ralf A.; Albertini, Francesca; Lomax, Antony J.; Ares, Carmen; Goitein, Gudrun; Hug, Eugen B.

In: International Journal of Radiation Oncology Biology Physics, Vol. 86, No. 1, 01.05.2013, p. 108-113.

Research output: Contribution to journalArticle

Thompson, Reid ; Schneider, Ralf A. ; Albertini, Francesca ; Lomax, Antony J. ; Ares, Carmen ; Goitein, Gudrun ; Hug, Eugen B. / Dose to the developing dentition during therapeutic irradiation : Organ at risk determination and clinical implications. In: International Journal of Radiation Oncology Biology Physics. 2013 ; Vol. 86, No. 1. pp. 108-113.
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