Dose-response relationship of levodopa with mood and anxiety in fluctuating parkinson's disease: A double-blind, placebo-controlled study

Robert A. Maricle, John Nutt, Rita J. Valentine, Julie Carter

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

We investigated the effect of levodopa on mood and anxiety in eight Parkinson's disease patients with motor fluctuations.Each patient received 0.0-, 0.5-, and 1.0-mg/kg/hr levodopa infusions in randomly assigned order under double-blind conditions on consecutive days. Mood elevation and anxiety reduction based on half-hourly patient rating and a corresponding increase in tapping speed occurred with active drug infusion but not placebo infusion. The effects were dose related. The higher-dose infusion rate produced more rapid onset, greater magnitude, and longer duration of response. We conclude that mood and anxiety fluctuations related to levodopa dosing are robust pharmacologic, and not placebo, effects.

Original languageEnglish (US)
Pages (from-to)1757-1760
Number of pages4
JournalNeurology
Volume45
Issue number9
StatePublished - 1995

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Levodopa
Parkinson Disease
Anxiety
Placebos
Placebo Effect
Pharmaceutical Preparations
Controlled
Dose
Placebo
Mood
Parkinson's Disease
Fluctuations

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Dose-response relationship of levodopa with mood and anxiety in fluctuating parkinson's disease : A double-blind, placebo-controlled study. / Maricle, Robert A.; Nutt, John; Valentine, Rita J.; Carter, Julie.

In: Neurology, Vol. 45, No. 9, 1995, p. 1757-1760.

Research output: Contribution to journalArticle

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