TY - JOUR
T1 - Dose-dependent systemic and regional hemodynamic effects of calcitonin gene-related peptide
AU - DiPette, D. J.
AU - Schwarzenberger, K.
AU - Kerr, N.
AU - Holland, O. B.
N1 - Funding Information:
From the Department of Medicine, Division of Endocrinology, Metabolism and Hypertension, University of Texas Medical Branch, Galveston, Texas. This work was presented in part at the American Federation of Clinical Research Southern Section and National Meetings 1987 and the annual meeting of the Council for High Blood Pressure Research of the American Heart Association 1986. This work was supported in part by the American Heart Association, Texas Affiliate grant 87R-654 and by NIH grant HL 37761. The authors wish to thank Adrienne Lambert for excellent secretarial assistance. Reprint requests: Donald J. DiPette, MD, Room 4.156, OJSH, E-72, University of Texas Medical Branch, Galveston, TX 77550.
PY - 1989
Y1 - 1989
N2 - The dose-response effects of infused calcitonin gene-related peptide (CGRP), a potent vasodilator, on systemic and regional hemodynamics in the conscious rat remain incompletely defined. The radioactive microsphere technique provided these determinations before and after the intravenous administration of vehicle or 22, 65, 220, and 2200 pmol of CGRP. Neither vehicle nor 22 pmol of CGRP significantly changed any systemic or regional hemodynamic parameter. Starting at the 65-pmol dose, CGRP significantly decreased mean blood pressure and total peripheral resistance, while increasing heart rate without changing cardiac output. CGRP significantly produced selective regional vasodilatory effects, with the coronary circulation being unusually sensitive. In contrast, CGRP caused significant increases in blood flow to the mesenteric and cutaneous circulations only at the two highest doses. CGRP increased plasma norepinephrine, epinephrine, and renin activity significantly at only the 2200-pmol dose. In conclusion, CGRP decreases blood pressure by peripheral vasodilation, with a threshold dose occurring between 22 and 65 pmol. In addition, the coronary circulation appears to be particularly sensitive to the vasodilatory properties of CGRP.
AB - The dose-response effects of infused calcitonin gene-related peptide (CGRP), a potent vasodilator, on systemic and regional hemodynamics in the conscious rat remain incompletely defined. The radioactive microsphere technique provided these determinations before and after the intravenous administration of vehicle or 22, 65, 220, and 2200 pmol of CGRP. Neither vehicle nor 22 pmol of CGRP significantly changed any systemic or regional hemodynamic parameter. Starting at the 65-pmol dose, CGRP significantly decreased mean blood pressure and total peripheral resistance, while increasing heart rate without changing cardiac output. CGRP significantly produced selective regional vasodilatory effects, with the coronary circulation being unusually sensitive. In contrast, CGRP caused significant increases in blood flow to the mesenteric and cutaneous circulations only at the two highest doses. CGRP increased plasma norepinephrine, epinephrine, and renin activity significantly at only the 2200-pmol dose. In conclusion, CGRP decreases blood pressure by peripheral vasodilation, with a threshold dose occurring between 22 and 65 pmol. In addition, the coronary circulation appears to be particularly sensitive to the vasodilatory properties of CGRP.
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U2 - 10.1097/00000441-198902000-00001
DO - 10.1097/00000441-198902000-00001
M3 - Article
C2 - 2784032
AN - SCOPUS:0024549939
SN - 0002-9629
VL - 297
SP - 65
EP - 70
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 2
ER -