Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue

Shaun F. Morrison; Wei Hua Cao; Christopher J. Madden

doi:10.1016/j.jtherbio.2004.08.006

Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue

Shaun F. Morrison, Wei Hua Cao, Christopher J. Madden

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

1. The rostral medullary raphe pallidus contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). 2. Disinhibition of neurons in the dorsomedial hypothalamus (DMH) stimulates BAT thermogenesis through activation of neurons in raphe pallidus. 3. An increase in BAT sympathetic outflow and BAT thermogenesis following microinjection of prostaglandin E2 into the preoptic area requires activation of both DMH neurons and raphe pallidus neurons. 4. DMH contains a population of neurons receiving a tonically- active GABAergic inhibition which mediate increases in BAT thermogenesis through stimulation of BAT sympathetic premotor neurons in raphe pallidus.

Original language	English (US)
Pages (from-to)	333-337
Number of pages	5
Journal	Journal of Thermal Biology
Volume	29
Issue number	7-8 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jtherbio.2004.08.006
State	Published - Oct 2004

Keywords

Bicuculline
Fever
GABA inhibition
Prostaglandin
Raphe pallidus
Sympathetic nerve activity
Thermoregulation

ASJC Scopus subject areas

Biochemistry
Physiology
General Agricultural and Biological Sciences
Developmental Biology

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10.1016/j.jtherbio.2004.08.006

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title = "Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue",

abstract = "1. The rostral medullary raphe pallidus contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). 2. Disinhibition of neurons in the dorsomedial hypothalamus (DMH) stimulates BAT thermogenesis through activation of neurons in raphe pallidus. 3. An increase in BAT sympathetic outflow and BAT thermogenesis following microinjection of prostaglandin E2 into the preoptic area requires activation of both DMH neurons and raphe pallidus neurons. 4. DMH contains a population of neurons receiving a tonically- active GABAergic inhibition which mediate increases in BAT thermogenesis through stimulation of BAT sympathetic premotor neurons in raphe pallidus.",

keywords = "Bicuculline, Fever, GABA inhibition, Prostaglandin, Raphe pallidus, Sympathetic nerve activity, Thermoregulation",

author = "Morrison, {Shaun F.} and Cao, {Wei Hua} and Madden, {Christopher J.}",

note = "Funding Information: This work was supported by US PHS National Institutes of Health Grants DK57838 and DK20378.",

year = "2004",

month = oct,

doi = "10.1016/j.jtherbio.2004.08.006",

language = "English (US)",

volume = "29",

pages = "333--337",

journal = "Journal of Thermal Biology",

issn = "0306-4565",

publisher = "Elsevier Limited",

number = "7-8 SPEC. ISS.",

}

TY - JOUR

T1 - Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue

AU - Morrison, Shaun F.

AU - Cao, Wei Hua

AU - Madden, Christopher J.

N1 - Funding Information: This work was supported by US PHS National Institutes of Health Grants DK57838 and DK20378.

PY - 2004/10

Y1 - 2004/10

N2 - 1. The rostral medullary raphe pallidus contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). 2. Disinhibition of neurons in the dorsomedial hypothalamus (DMH) stimulates BAT thermogenesis through activation of neurons in raphe pallidus. 3. An increase in BAT sympathetic outflow and BAT thermogenesis following microinjection of prostaglandin E2 into the preoptic area requires activation of both DMH neurons and raphe pallidus neurons. 4. DMH contains a population of neurons receiving a tonically- active GABAergic inhibition which mediate increases in BAT thermogenesis through stimulation of BAT sympathetic premotor neurons in raphe pallidus.

AB - 1. The rostral medullary raphe pallidus contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). 2. Disinhibition of neurons in the dorsomedial hypothalamus (DMH) stimulates BAT thermogenesis through activation of neurons in raphe pallidus. 3. An increase in BAT sympathetic outflow and BAT thermogenesis following microinjection of prostaglandin E2 into the preoptic area requires activation of both DMH neurons and raphe pallidus neurons. 4. DMH contains a population of neurons receiving a tonically- active GABAergic inhibition which mediate increases in BAT thermogenesis through stimulation of BAT sympathetic premotor neurons in raphe pallidus.

KW - Bicuculline

KW - Fever

KW - GABA inhibition

KW - Prostaglandin

KW - Raphe pallidus

KW - Sympathetic nerve activity

KW - Thermoregulation

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DO - 10.1016/j.jtherbio.2004.08.006

M3 - Article

AN - SCOPUS:4744365750

SN - 0306-4565

VL - 29

SP - 333

EP - 337

JO - Journal of Thermal Biology

JF - Journal of Thermal Biology

IS - 7-8 SPEC. ISS.

ER -

Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue

Abstract

Keywords

ASJC Scopus subject areas

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