Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue

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Abstract

1. The rostral medullary raphe pallidus contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). 2. Disinhibition of neurons in the dorsomedial hypothalamus (DMH) stimulates BAT thermogenesis through activation of neurons in raphe pallidus. 3. An increase in BAT sympathetic outflow and BAT thermogenesis following microinjection of prostaglandin E2 into the preoptic area requires activation of both DMH neurons and raphe pallidus neurons. 4. DMH contains a population of neurons receiving a tonically- active GABAergic inhibition which mediate increases in BAT thermogenesis through stimulation of BAT sympathetic premotor neurons in raphe pallidus.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalJournal of Thermal Biology
Volume29
Issue number7-8 SPEC. ISS.
DOIs
StatePublished - Oct 1 2004

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Keywords

  • Bicuculline
  • Fever
  • GABA inhibition
  • Prostaglandin
  • Raphe pallidus
  • Sympathetic nerve activity
  • Thermoregulation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Agricultural and Biological Sciences(all)
  • Developmental Biology

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