Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

1. The rostral medullary raphe pallidus contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). 2. Disinhibition of neurons in the dorsomedial hypothalamus (DMH) stimulates BAT thermogenesis through activation of neurons in raphe pallidus. 3. An increase in BAT sympathetic outflow and BAT thermogenesis following microinjection of prostaglandin E2 into the preoptic area requires activation of both DMH neurons and raphe pallidus neurons. 4. DMH contains a population of neurons receiving a tonically- active GABAergic inhibition which mediate increases in BAT thermogenesis through stimulation of BAT sympathetic premotor neurons in raphe pallidus.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalJournal of Thermal Biology
Volume29
Issue number7-8 SPEC. ISS.
DOIs
StatePublished - Oct 2004

Fingerprint

Brown Adipose Tissue
brown adipose tissue
Thermogenesis
brain stem
heat production
Brain Stem
Neurons
neurons
Tissue
hypothalamus
Hypothalamus
Chemical activation
preoptic area
Preoptic Area
Microinjections
Dinoprostone
prostaglandins
Population

Keywords

  • Bicuculline
  • Fever
  • GABA inhibition
  • Prostaglandin
  • Raphe pallidus
  • Sympathetic nerve activity
  • Thermoregulation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physiology

Cite this

Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue. / Morrison, Shaun; Cao, Wei Hua; Madden, Christopher (Chris).

In: Journal of Thermal Biology, Vol. 29, No. 7-8 SPEC. ISS., 10.2004, p. 333-337.

Research output: Contribution to journalArticle

@article{f608e026575e4222b3421b39a5d30283,
title = "Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue",
abstract = "1. The rostral medullary raphe pallidus contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). 2. Disinhibition of neurons in the dorsomedial hypothalamus (DMH) stimulates BAT thermogenesis through activation of neurons in raphe pallidus. 3. An increase in BAT sympathetic outflow and BAT thermogenesis following microinjection of prostaglandin E2 into the preoptic area requires activation of both DMH neurons and raphe pallidus neurons. 4. DMH contains a population of neurons receiving a tonically- active GABAergic inhibition which mediate increases in BAT thermogenesis through stimulation of BAT sympathetic premotor neurons in raphe pallidus.",
keywords = "Bicuculline, Fever, GABA inhibition, Prostaglandin, Raphe pallidus, Sympathetic nerve activity, Thermoregulation",
author = "Shaun Morrison and Cao, {Wei Hua} and Madden, {Christopher (Chris)}",
year = "2004",
month = "10",
doi = "10.1016/j.jtherbio.2004.08.006",
language = "English (US)",
volume = "29",
pages = "333--337",
journal = "Journal of Thermal Biology",
issn = "0306-4565",
publisher = "Elsevier Limited",
number = "7-8 SPEC. ISS.",

}

TY - JOUR

T1 - Dorsomedial hypothalamic and brainstem pathways controlling thermogenesis in brown adipose tissue

AU - Morrison, Shaun

AU - Cao, Wei Hua

AU - Madden, Christopher (Chris)

PY - 2004/10

Y1 - 2004/10

N2 - 1. The rostral medullary raphe pallidus contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). 2. Disinhibition of neurons in the dorsomedial hypothalamus (DMH) stimulates BAT thermogenesis through activation of neurons in raphe pallidus. 3. An increase in BAT sympathetic outflow and BAT thermogenesis following microinjection of prostaglandin E2 into the preoptic area requires activation of both DMH neurons and raphe pallidus neurons. 4. DMH contains a population of neurons receiving a tonically- active GABAergic inhibition which mediate increases in BAT thermogenesis through stimulation of BAT sympathetic premotor neurons in raphe pallidus.

AB - 1. The rostral medullary raphe pallidus contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). 2. Disinhibition of neurons in the dorsomedial hypothalamus (DMH) stimulates BAT thermogenesis through activation of neurons in raphe pallidus. 3. An increase in BAT sympathetic outflow and BAT thermogenesis following microinjection of prostaglandin E2 into the preoptic area requires activation of both DMH neurons and raphe pallidus neurons. 4. DMH contains a population of neurons receiving a tonically- active GABAergic inhibition which mediate increases in BAT thermogenesis through stimulation of BAT sympathetic premotor neurons in raphe pallidus.

KW - Bicuculline

KW - Fever

KW - GABA inhibition

KW - Prostaglandin

KW - Raphe pallidus

KW - Sympathetic nerve activity

KW - Thermoregulation

UR - http://www.scopus.com/inward/record.url?scp=4744365750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4744365750&partnerID=8YFLogxK

U2 - 10.1016/j.jtherbio.2004.08.006

DO - 10.1016/j.jtherbio.2004.08.006

M3 - Article

VL - 29

SP - 333

EP - 337

JO - Journal of Thermal Biology

JF - Journal of Thermal Biology

SN - 0306-4565

IS - 7-8 SPEC. ISS.

ER -