Doppler optical microangiography improves the quantification of local fluid flow and shear stress within 3-D porous constructs

Yali Jia, Lin An, Ruikang K. Wang

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) with a phase-resolved method, for improved assessment of local fluid flow and its derived parameters, shear stress, and interconnectivity, within highly scattering porous constructs. Compared with DOCT, we demonstrate a dramatic improvement of DOMAG in quantifying flow-related properties within scaffolds in situ for functional tissue engineering.

Original languageEnglish (US)
Article number050504
JournalJournal of biomedical optics
Volume14
Issue number5
DOIs
StatePublished - 2009

Keywords

  • Fluid flow
  • Optical coherence tomography
  • Optical microangiography
  • Porous scaffold
  • Shear stress
  • Tissue engineering

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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