Doppler evaluation of severity of mitral regurgitation: Relation to pulmonary venous blood flow patterns in an animal study

Dag E. Teien, Michael Jones, Takahiro Shiota, Izumi Yamada, David J. Sahn

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Objectives. This study examined the influence of regurgitant volume on pulmonary venous blood flow patterns in an animal model with quantifiable mitral regurgitation. Background. Systolic pulmonary venous blood flow is influenced by atrial filling and compliance and ventricular output and by the presence of mitral regurgitation. The quantitative severity of the regurgitant volume itself is difficult to judge in clinical examinations. Methods. Six sheep with chronic mitral regurgitation produced by previous operation to create chordal damage were examined. At reoperation the heart was exposed and epicardial echocardiography performed. Pulmonary venous blood flow waveforms were recorded by pulsed Doppler under color flow Doppler guidance using a Vingmed 750 scanner. The pulmonary venous systolic inflow to the left atrium was expressed as a fraction of the total inflow velocity time integral. Flows across the aortic and mitral valves were recorded by electromagnetic flowmeters balanced against each other. Pressures in the left ventricle and left atrium were measured directly with high fidelity manometer-tipped catheters. Preload and afterload were systematically manipulated, resulting in 24 stable hemodynamic states. Results. Simple logarithmic correlation between the regurgitant volume and size of a positive or negative pulmonary venous inflow velocity time integral during systole was good (r = -0.841). By stepwise linear regression analysis with pulmonary venous negative systolic velocity time integral as a dependent variable compared with the regurgitant volume, fractional shortening, left atrial ν wave size, systemic vascular resistance and left ventricular systolic pressure, only contributions from ν wave size and regurgitant volume (r = 0.80) reached statistical significance in determining pulmonary venous negative systolic flow. Conclusions. Evaluation of systolic pulmonary venous blood flow velocity time integral can give valuable information helpful for estimating the regurgitant volume secondary to mitral regurgitation.

Original languageEnglish (US)
Pages (from-to)264-268
Number of pages5
JournalJournal of the American College of Cardiology
Volume25
Issue number1
DOIs
StatePublished - Jan 1995

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Doppler evaluation of severity of mitral regurgitation: Relation to pulmonary venous blood flow patterns in an animal study'. Together they form a unique fingerprint.

Cite this