Dopaminergic regulation of prolactin and growth hormone synthesis in rat pituitary tumor cells

Cecilia Y. Cheung, Shlomo Melmed, Glenn D. Braunstein

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The dopaminergic regulation of prolactin (PRL) and growth hormone (GH) synthesis were studied in monolayer cultures of rat pituitary tumor (GH3) cells. PRL synthesis could not be inhibited by dopamine at concentrations ranging from 10-9 to 10-5 M. Bromocriptine inhibited PRL synthesis only at the very high concentration of 10-5 M, and this effect was not reversible by metoclopramide. GH synthesis was inhibited by 10-6 and 10-5 M dopamine but not by bromocriptine, and the dopamine effect was blocked by metoclopramide. These results suggest the existence of a defective dopaminergic regulation of PRL and GH synthesis in GH3 cells.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalBrain research
Volume270
Issue number1
DOIs
StatePublished - Jun 27 1983

Keywords

  • dopaminergic regulation
  • growth hormone
  • pituitary tumor
  • prolactin
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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