Dopamine Transporters Decrease with Age

Nora D. Volkow, Yu Shin Ding, Joanna S. Fowler, Gene Jack Wang, Jean Logan, S. John Gatley, Robert Hitzemann, Gwenn Smith, Suzanne D. Fields, Ruben Gur

Research output: Contribution to journalArticle

218 Citations (Scopus)

Abstract

Postmortem studies have documented degeneration of dopamine cells with age, but the changes that occur in healthy aging individuals is less clear. The purpose of this study was to evaluate the extent to which age-induced changes in dopamine transporters occur in subjects with no evidence of motor impairment. Methods: We evaluated 23 right-handed healthy volunteers (age range 20-74 yr) using PET and [11C]d-fhreo-methylphenidate. The ratio of the distribution volume for [11C]d-threo-methylphenidate in striatum to that in cerebellum was used as model parameter for dopamine transporter availability (Bmax/Kd + 1). Results: Dopamine transporter availability was significantly lower in subjects >40 yr of age than in those

Original languageEnglish (US)
Pages (from-to)554-559
Number of pages6
JournalJournal of Nuclear Medicine
Volume37
Issue number4-6
StatePublished - Apr 1996
Externally publishedYes

Fingerprint

Dopamine Plasma Membrane Transport Proteins
Methylphenidate
Cerebellum
Dopamine
Healthy Volunteers

Keywords

  • Degeneration
  • Dopamine transporters
  • PET

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Volkow, N. D., Ding, Y. S., Fowler, J. S., Wang, G. J., Logan, J., Gatley, S. J., ... Gur, R. (1996). Dopamine Transporters Decrease with Age. Journal of Nuclear Medicine, 37(4-6), 554-559.

Dopamine Transporters Decrease with Age. / Volkow, Nora D.; Ding, Yu Shin; Fowler, Joanna S.; Wang, Gene Jack; Logan, Jean; Gatley, S. John; Hitzemann, Robert; Smith, Gwenn; Fields, Suzanne D.; Gur, Ruben.

In: Journal of Nuclear Medicine, Vol. 37, No. 4-6, 04.1996, p. 554-559.

Research output: Contribution to journalArticle

Volkow, ND, Ding, YS, Fowler, JS, Wang, GJ, Logan, J, Gatley, SJ, Hitzemann, R, Smith, G, Fields, SD & Gur, R 1996, 'Dopamine Transporters Decrease with Age', Journal of Nuclear Medicine, vol. 37, no. 4-6, pp. 554-559.
Volkow ND, Ding YS, Fowler JS, Wang GJ, Logan J, Gatley SJ et al. Dopamine Transporters Decrease with Age. Journal of Nuclear Medicine. 1996 Apr;37(4-6):554-559.
Volkow, Nora D. ; Ding, Yu Shin ; Fowler, Joanna S. ; Wang, Gene Jack ; Logan, Jean ; Gatley, S. John ; Hitzemann, Robert ; Smith, Gwenn ; Fields, Suzanne D. ; Gur, Ruben. / Dopamine Transporters Decrease with Age. In: Journal of Nuclear Medicine. 1996 ; Vol. 37, No. 4-6. pp. 554-559.
@article{01e2b70b5d154dcb9ccbc0e50ebf2b4c,
title = "Dopamine Transporters Decrease with Age",
abstract = "Postmortem studies have documented degeneration of dopamine cells with age, but the changes that occur in healthy aging individuals is less clear. The purpose of this study was to evaluate the extent to which age-induced changes in dopamine transporters occur in subjects with no evidence of motor impairment. Methods: We evaluated 23 right-handed healthy volunteers (age range 20-74 yr) using PET and [11C]d-fhreo-methylphenidate. The ratio of the distribution volume for [11C]d-threo-methylphenidate in striatum to that in cerebellum was used as model parameter for dopamine transporter availability (Bmax/Kd + 1). Results: Dopamine transporter availability was significantly lower in subjects >40 yr of age than in those",
keywords = "Degeneration, Dopamine transporters, PET",
author = "Volkow, {Nora D.} and Ding, {Yu Shin} and Fowler, {Joanna S.} and Wang, {Gene Jack} and Jean Logan and Gatley, {S. John} and Robert Hitzemann and Gwenn Smith and Fields, {Suzanne D.} and Ruben Gur",
year = "1996",
month = "4",
language = "English (US)",
volume = "37",
pages = "554--559",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "4-6",

}

TY - JOUR

T1 - Dopamine Transporters Decrease with Age

AU - Volkow, Nora D.

AU - Ding, Yu Shin

AU - Fowler, Joanna S.

AU - Wang, Gene Jack

AU - Logan, Jean

AU - Gatley, S. John

AU - Hitzemann, Robert

AU - Smith, Gwenn

AU - Fields, Suzanne D.

AU - Gur, Ruben

PY - 1996/4

Y1 - 1996/4

N2 - Postmortem studies have documented degeneration of dopamine cells with age, but the changes that occur in healthy aging individuals is less clear. The purpose of this study was to evaluate the extent to which age-induced changes in dopamine transporters occur in subjects with no evidence of motor impairment. Methods: We evaluated 23 right-handed healthy volunteers (age range 20-74 yr) using PET and [11C]d-fhreo-methylphenidate. The ratio of the distribution volume for [11C]d-threo-methylphenidate in striatum to that in cerebellum was used as model parameter for dopamine transporter availability (Bmax/Kd + 1). Results: Dopamine transporter availability was significantly lower in subjects >40 yr of age than in those

AB - Postmortem studies have documented degeneration of dopamine cells with age, but the changes that occur in healthy aging individuals is less clear. The purpose of this study was to evaluate the extent to which age-induced changes in dopamine transporters occur in subjects with no evidence of motor impairment. Methods: We evaluated 23 right-handed healthy volunteers (age range 20-74 yr) using PET and [11C]d-fhreo-methylphenidate. The ratio of the distribution volume for [11C]d-threo-methylphenidate in striatum to that in cerebellum was used as model parameter for dopamine transporter availability (Bmax/Kd + 1). Results: Dopamine transporter availability was significantly lower in subjects >40 yr of age than in those

KW - Degeneration

KW - Dopamine transporters

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=0030115973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030115973&partnerID=8YFLogxK

M3 - Article

C2 - 8691238

AN - SCOPUS:0030115973

VL - 37

SP - 554

EP - 559

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 4-6

ER -