Dopamine receptors set the pattern of activity generated in subthalamic neurons

J. Baufreton, Z. T. Zhu, M. Garret, B. Bioulac, S. W. Johnson, A. I. Taupignon

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Information processing in the brain requires adequate background neuronal activity. As Parkinson's disease progresses, patients typically become akinetic; the death of dopaminergic neurons leads to a dopamine-depleted state, which disrupts information processing related to movement in a brain area called the basal ganglia. Using agonists of dopamine receptors in the D1 and D2 families on rat brain slices, we show that dopamine receptors in these two families govern the firing pattern of neurons in the subthalamic nucleus, a crucial part of the basal ganglia. We propose a conceptual frame, based on specific properties of dopamine receptors, to account for the dominance of different background firing patterns in normal and dopamine-depleted states.

Original languageEnglish (US)
Pages (from-to)1771-1777
Number of pages7
JournalFASEB Journal
Issue number13
StatePublished - Nov 2005
Externally publishedYes


  • Basal ganglia
  • Burst-firing
  • Slow-wave sleep
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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