Dopamine receptors set the pattern of activity generated in subthalamic neurons

J. Baufreton, Z. T. Zhu, M. Garret, B. Bioulac, Steven Johnson, A. I. Taupignon

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Information processing in the brain requires adequate background neuronal activity. As Parkinson's disease progresses, patients typically become akinetic; the death of dopaminergic neurons leads to a dopamine-depleted state, which disrupts information processing related to movement in a brain area called the basal ganglia. Using agonists of dopamine receptors in the D1 and D2 families on rat brain slices, we show that dopamine receptors in these two families govern the firing pattern of neurons in the subthalamic nucleus, a crucial part of the basal ganglia. We propose a conceptual frame, based on specific properties of dopamine receptors, to account for the dominance of different background firing patterns in normal and dopamine-depleted states.

Original languageEnglish (US)
Pages (from-to)1771-1777
Number of pages7
JournalFASEB Journal
Volume19
Issue number13
DOIs
StatePublished - Nov 2005

Fingerprint

Dopamine Receptors
Neurons
Brain
neurons
Basal Ganglia
dopamine
Automatic Data Processing
brain
Dopamine
Subthalamic Nucleus
Dopamine D1 Receptors
Dopamine D2 Receptors
Parkinson disease
Dopaminergic Neurons
Dopamine Agonists
basal area
agonists
Parkinson Disease
Rats
death

Keywords

  • Basal ganglia
  • Burst-firing
  • Slow-wave sleep
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Baufreton, J., Zhu, Z. T., Garret, M., Bioulac, B., Johnson, S., & Taupignon, A. I. (2005). Dopamine receptors set the pattern of activity generated in subthalamic neurons. FASEB Journal, 19(13), 1771-1777. https://doi.org/10.1096/fj.04-3401hyp

Dopamine receptors set the pattern of activity generated in subthalamic neurons. / Baufreton, J.; Zhu, Z. T.; Garret, M.; Bioulac, B.; Johnson, Steven; Taupignon, A. I.

In: FASEB Journal, Vol. 19, No. 13, 11.2005, p. 1771-1777.

Research output: Contribution to journalArticle

Baufreton, J, Zhu, ZT, Garret, M, Bioulac, B, Johnson, S & Taupignon, AI 2005, 'Dopamine receptors set the pattern of activity generated in subthalamic neurons', FASEB Journal, vol. 19, no. 13, pp. 1771-1777. https://doi.org/10.1096/fj.04-3401hyp
Baufreton, J. ; Zhu, Z. T. ; Garret, M. ; Bioulac, B. ; Johnson, Steven ; Taupignon, A. I. / Dopamine receptors set the pattern of activity generated in subthalamic neurons. In: FASEB Journal. 2005 ; Vol. 19, No. 13. pp. 1771-1777.
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