Dopamine Receptors

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dopamine receptors are rhodopsin-like seven-transmembrane receptors (also called G protein-coupled receptors) that mediate the central and peripheral actions of dopamine. Dopamine receptors are most abundant in pituitary and brain, particularly in the basal forebrain, and are also found in the retina and peripheral organs such as the kidney. Stimulation of dopamine receptors modulates excretion of sodium by the kidney, and both cell division and hormone synthesis and secretion in the pituitary. Brain dopamine receptors regulate movement and locomotion, motivation, and working memory. Five subtypes of mammalian dopamine receptors have been identified that are divided into D1-like (D1 and D5) or D2-like (D2, D3, and D4) groups. The D1-like receptors couple primarily to the Gαs family of G proteins (Gαs and Gαolf), whereas the D2-like receptors couple primarily to the Gαi/o family. Drugs that block D2 receptors are useful for the treatment of schizophrenia and other psychoses, while drugs that stimulate D1-like or D2-like receptors alleviate the motor symptoms that result from degeneration of dopamine-containing neurons in Parkinson's disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages169-173
Number of pages5
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013
Externally publishedYes

Keywords

  • Adenylate cyclase
  • Arrestin
  • Calcium
  • Cyclic AMP
  • Dopamine
  • Dopamine receptor
  • G protein
  • G protein-coupled receptors
  • Neurotransmitter
  • Parkinson's disease
  • Protein kinase
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Neve, K. (2013). Dopamine Receptors. In Encyclopedia of Biological Chemistry: Second Edition (pp. 169-173). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00326-1